乳腺癌的组织学分级与C-erbB_2过度表达及激素水平的关系探讨  

Histological grading and its relation between C-erb B_2 superexpression and hormone level

作　　者：许励[1] 曹维海[2] 于大有[2] 王树生[2] 

机构地区：[1]浙江省人民医院,310014 [2]齐齐哈尔市第一医院

出　　处：《黑龙江医药科学》1999年第3期6-7,共2页Heilongjiang Medicine and Pharmacy

摘　　要：本文根据Blorm－Richarcisonde分级标准对46例浸润性导管癌进行分析，同时采用S－P法对其进行C－erbB2癌基因和ER、PR免疫组织化学标记。结果：组织学Ⅰ级Ⅱ例，C－erbB2癌基因和ER、PR的阳性率分别为18．12％、63％和、54％；组织学Ⅱ级25例，C－erbB2癌基因和ER、PR的阳性率分别为28％、48％和32％组织学Ⅲ级10例，C－erbB2癌基因和ER、PR的阳性率分别为40％、20％和10％。从而表明组织学分级越差，C－erbB2癌基因的过度表达越强，ER、PR阳性率越低，淋巴结转移的机率越高．组织学分级与C－erbB2癌基因的过度表达呈正相关，与ER、PR水平呈负相关，与淋巴结转移率呈正相关．C－erbB2癌基因过度表达预后差，复发及转移率高，RP、PR阳性率高提示预后好，复发、转移率低。We analyzed 46 cases of infiltraive brean cancer according to Blorm-Richarcisond grading standard, and carried out C-erbB2 oncogene, ER and PR immunohistochemistry labelling to them. The results showed 11 cases of histology type Ⅰ with the positive rates of C-erbB2 oncogene, ER and PR were 18.12%, 63% and 54%; Respectively; 25 cases of histology type Ⅱ with positive rates of C-erbB2 oncogene, ER and PR were 28%, 48% and 32%, respectively; 10 cases of histology type Ⅲ with positive rates of C-erbB2 oncogene, ER and PR were 40%, 20% and 10%, respectively. That means that the lower the histological grade is, the higher the C-erbB2 oncogene superexpression is, and the lower the ER and PR positive rates and the higher the chance of lymphatic metastasin. There is a positive relation of histology grade with C-erb B2 oncogene superexpression, a negtive retation with ER and PR and a positive relation with lymphation and mestastasis rate. C-erbB2 oncogene superexpresion indicates unfavourable prognosis, high recuremce rate and metheis rate. And high ER and PR positive rae indicates fovorable prognosis, low recurence rate and metaStasis rate.

关 键 词：乳腺癌 C-ERBB2 癌基因 雌激素 孕激素 

分 类 号：R737.902[医药卫生—肿瘤]