胃幽门螺杆菌与胃细胞凋亡的研究  

Relationship between gastric H.pylori infection and cell apoptosis

作　　者：彭惠[1] 潘国宗[1] 鲁重美[1] 

机构地区：[1]中国医学科学院中国协和医科大学北京协和医院

出　　处：《中华消化杂志》1999年第3期154-155,共2页Chinese Journal of Digestion

摘　　要：目的探讨细胞凋亡在幽门螺杆菌（Ｈｐ）阳性胃十二指肠疾病中的意义。方法用原位凋亡细胞观察Ｈｐ对胃上皮细胞凋亡的影响。结果在Ｈｐ（＋）胃十二指肠疾病，除胃癌外均比Ｈｐ（－）的细胞凋亡率高，其顺序是十二指肠溃疡＞胃溃疡＞浅表性胃炎＞萎缩性胃炎＞胃癌。十二指肠溃疡和胃溃疡还可见到梯状ＤＮＡ现象。结论Ｈｐ可诱导细胞凋亡；细胞凋亡与细胞增殖失衡程度和水平的不同，有可能是导致不同的胃十二指肠疾病的原因之一。Objective To explore the significance of cell apoptosis in gastroduodenal diseases infected with H.pylori. Methods The effects of H.pylori on the gastric epithelium were percieved by in situ apoptosis detection and DNA ladder pattern. Results By the use of in situ apoptosis detection, its rate in various gastroduodenal diseases infected with H.pylori except for gastric carcinoma was higher than in those uninfected. It was in decreasing order of duodenal ulcer>gastric ulcer>superficial gastritis>atrophic gastritis>gastric cancer. The DNA ladder could be observed in duodenal ulcer and gastric ulcer patients. Conclusions H.pylori may enhance cell apoptosis, and perhaps result in a diversity of gastroduodenal diseases due to the imbalance of apoptosis and cell proliferation.

关 键 词：幽门螺杆菌 细胞凋亡 细胞增殖 胃十二指肠疾病 

分 类 号：R573.02[医药卫生—消化系统]