功能化洋葱状富勒烯在裸鼠体内的流动  

Fluidity of onion-like fullerenes in mice after a functionalization modification

作　　者：张宏伟[1] 王艳[1] 王崇宇[2] 张雪莹[1] 郭俊杰[1] 王晓敏[1] 

机构地区：[1]太原理工大学材料科学与工程学院,山西太原030024 [2]浙江海洋学院医学院,浙江舟山316004

出　　处：《新型炭材料》2010年第5期382-388,共7页New Carbon Materials

基　　金：国家自然科学基金(50772069);教育部资助项目(NECT-08-0888;209018)~~

摘　　要：采用L-半胱氨酸盐酸盐,通过化合接枝法对洋葱状富勒烯进行功能化,合成水溶性L-半胱氨酸富勒烯衍生物。利用扫描电子显微镜(SEM)、X射线衍射(XRD)、红外光谱(IR)、热重分析(TGA)及X射线能谱分析(XPS)对所制样品进行表征。结果表明:L-半胱氨酸富勒烯衍生物表面具有-OH、-NH3等亲水性基团,水溶性良好。裸鼠实验表明,合成的L-半胱氨酸富勒烯衍生物在生物体组织细胞中具有很好的分布,可以顺利溶入生物体体液并具备良好的流动性。Water-soluble onion-like fullerene（OLF）derivatives were prepared by chemical bonding of L-cysteine,an important amino acid in organisms,to OLFs.The L-cysteine OLFs were characterized by SEM,XRD,IR,TGA and XPS.Results showed that hydrophilic groups added to the surface of OLFs such as-OH and-NH3 made L-cysteine OLFs good water-soluble derivatives.Experiments in mice demonstrated that the water-soluble fullerene derivatives were well distributed in the histolytic organism because of their excellent solubility and fluidity in humoral liquid.

关 键 词：L-半胱氨酸富勒烯衍生物 水溶性 功能化 流动性 

分 类 号：R73-3[医药卫生—肿瘤]