细胞代谢解毒酶CYP1A1、GSTM1基因多态性与吸烟对男性肺鳞癌发病的影响  

Effects of metabolic enzyme CYP1A1 and GSTM1 gene polymorphisms and smoking factors on the occurrence of male lung squamous cell carcinoma

作　　者：宋宝[1] 刘杰[2] 黄海燕[3] 王兴武[1] 郑燕[1] 韩金祥[3] 王哲海[2] 

机构地区：[1]山东省肿瘤医院基础研究中心,山东济南250117 [2]山东省肿瘤医院内三科,山东济南250117 [3]山东省医学科学院医药生物技术研究中心,山东济南250062

出　　处：《基础医学与临床》2010年第11期1193-1196,共4页Basic and Clinical Medicine

基　　金：山东省卫生厅项目(2007HW135);山东省自然科学基金(Q2007C11)

摘　　要：目的探讨细胞代谢解毒酶细胞色素P450酶1A1(CYP1A1)、谷胱甘肽S-转硫酶M1(GSTM1)基因多态性和吸烟因素对男性肺鳞癌发病的影响。方法采用基因芯片技术对125例男性肺鳞癌患者和125例男性健康对照者CYP1A1、GSTM1基因多态性进行检测。结果 CYP1A1m2位点GG基因型和GSTM1缺失基因型在肺鳞癌组与健康对照者间存在显著性差异(P<0.05)。吸烟者携带CYP1A1m2位点至少一个变异G等位基因或携带GSTM1缺失型者患肺鳞癌的危险性进一步显著增加,OR值分别为4.50和3.81(P<0.01)。结论吸烟与CYP1A1、GSTM1基因多态性与男性肺鳞癌的发生有关。Objective To explore the effect of cytochrome P450 enzyme 1A1（CYP1A1） and glutathione-S-transferase M1（GSTM1） genetic polymorphism and smoking factor on the occurrence of male lung squamous carcinoma.Methods CYP1A1 and GSTM1 genotypes were detected with oligonucleotidechip technique in 125 male lung squamous carcinoma patients and 125 healthy controls.Results Frequencies of GG genotype at CYP1A1 m2 site and frequencies of GSTM1 null genotypes were significantly increased in lung cancer group compared to control group（P0.05）.When stratified by smoking status,there were increased risk for smokers in lung cancer cases carrying at least one G allele of CYP1A1 m2 site or GSTM1 null genotype,the odds ratios were 4.50 or 3.18 respectively（P0.01）.Conclusion CYP1A1 and GSTM1 gene polymorphism were associated with the occurrence of male lung squamous cell carcinoma,smoking factors and CYP1A1 and GSTM1 polymorphism have a synergistic effect.

关 键 词：细胞色素P450酶1A1 谷胱甘肽S-转硫酶M1 基因多态性 肺鳞癌 

分 类 号：R734.2[医药卫生—肿瘤]