不同病理阶段食管癌患者生命质量评价  

ASSESSMENT ON QUALITY OF LIFE FOR ESOPHAGEAL CANCER IN DIFFERENT PATHOLOGICAL STAGE

作　　者：田智[1] 魏文强[2] 李变云[3] 黄文治[1] 杨娟[1] 宋国慧 赵德利 杨春霞[1] 乔友林[2] 

机构地区：[1]四川大学华西公共卫生学院流行病学教研室,成都610041 [2]中国医学科学院肿瘤研究所 肿瘤医院流行病室 [3]河南省林州市肿瘤医院 [4]河北省磁县肿瘤医院 [5]山东省肥城市人民医院

出　　处：《现代预防医学》2010年第22期4203-4204,4210,共3页Modern Preventive Medicine

基　　金：国家科技支撑计划项目(2006BAI02A15)

摘　　要：[目的]本研究旨在比较食管癌不同病理阶段患者治疗前后的生命质量,为食管癌早诊早治方案的进一步推广实施提供理论依据。[方法]在食管癌早诊早治项目地区选取2007~2008年进入项目指定医院接受治疗的鳞重增及以上患者作为研究对象,采用自行设计的食管癌生命质量评价量表收集其生命质量信息,并比较各调查时间不同病理阶段患者的得分差异。[结果]共收集到重度增生/原位癌患者132例、早期癌患者67例、中晚期癌患者71例。重度增生/原位癌患者、早期癌和中晚期癌患者生命质量总分在治疗前分别为0.886±0.082,0.805±0.123,0.658±0.163;治疗后1月为0.857±0.091,0.759±0.140,0.608±0.122;半年为0.874±0.062,0.785±0.127,0.640±0.150和1年0.888±0.049,0.800±0.130,0.651±0.134。不同病理阶段患者癌症普适性得分、食管癌特异性得分及生命质量总分差异有统计学意义（P﹤0.05）。[结论]食管癌癌前病变以及早期癌患者的生命质量在治疗前后均高于中晚期癌患者,说明在食管癌高发区开展筛查及早诊早治可显著提高患者的生命质量。[Objective] To investigate and analyze quality of life（QOL） of patients with esophageal cancer in the follow-ing four areas-Linxian of Henan province,Cixian of Hebei province,Yanting of Sichuan province and Feicheng of Shandong province.Further,to clarify the changes in QOL and lay the theoretical foundation for further implementation of early diagnosis and treatment.[Methods] During 2007 to 2008,patients with esophageal severe atypical hyperplasia or cancer treated in four hospitals were interviewed.Totally,132 patients with precancerous lesions,67 early cancers and 71 advanced cancers were re-cruited.A self-made QOL questionnaire for esophageal cancers was applied to collect information on their QOL at different sur-vey time（before treatment,one month after treatment,six months and one year after treatment）.The average scores of QOL were described and compared among the patients with different pathological stage.[Results] The average total scores were 0.886 ± 0.082,0.805 ± 0.123,and 0.658 ± 0.163,respectively,for patients with precancerous lesions,early cancers and advanced cancers before treatment;0.857± 0.091,0.759 ± 0.140 and 0.608 ± 0.122 one month after treatment;0.874 ± 0.062,0.785 ± 0.127 and 0.640±0.150 six months after treatment;and 0.888 ± 0.049,0.800 ± 0.130 and 0.651 ± 0.134 one year after treatment.The average scores in the same survey time decreased significantly from precancerous lesions,early cancer to advanced cancer（P﹤0.05）.[Conclusion] early detection and treatment can improve the QOL of patients with esophageal cancer.

关 键 词：食管癌 早期癌 中晚期癌 生命质量 早诊早治 

分 类 号：R735.1[医药卫生—肿瘤]