基于糖链结构的乳腺癌研究  

Recent research developments in glycan-based breast cancer

作　　者：李炜[1] 吴士良[1] 

机构地区：[1]苏州大学医学部生物化学与分子生物学系,生化工程研究所,苏州215123

出　　处：《生命的化学》2010年第5期695-698,共4页Chemistry of Life

基　　金：国家自然科学基金(30670462)资助

摘　　要：自从Dwek教授提出糖生物学的概念以来,人们逐渐意识到聚糖结构的多变性,并开始重视将糖生物学作为一个新视角为生物医学研究带来的启发。乳腺癌是妇女常见的恶性肿瘤,其发病率正在逐年上升。随着早期诊断及综合治疗方法的改进,患者死亡率有所下降,然而乳腺癌仍然对妇女健康造成了严重威胁。本文从糖链结构的角度,对近年涉及乳腺癌诊断、治疗、预后相关的基于糖链结构的研究作一回顾。Since Professor Dwek introduced concept of glycobiology,remarkable structural variability of glycan has been gradually recognized,and more and more attention is being paid to glycobiology＇s role as a new perspective for biomedical research.Breast cancer is a malignancy commonly related to women,its incidence rate rises year on year.With the improvements of breast cancer diagnostics and comprehensive treatments,its mortality decreased,but it remains a serious threat to women health.In this article,recent glycan-based breast cancer researches were reviewed concerning clinical fields,such as diagnosis,treatment and prognosis.

关 键 词：糖链 乳腺癌 疫苗 

分 类 号：R737.9[医药卫生—肿瘤]