抑郁症事件相关电位的前瞻性病例对照研究  

A prospective case-control study of the ERPs in depression

作　　者：孙燕[1] 李莉[1] 武克文 段慧君[1] 尚卫东 王彦芳[1] 彭菊意[1] 马锦堂[1] 张克让[1] 

机构地区：[1]山西医科大学第一医院精神卫生科,太原030001 [2]山西省荣军精神康宁医院 [3]山西省大同市社会精神病院

出　　处：《中华行为医学与脑科学杂志》2010年第10期904-906,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：基金项目：国家自然科学基金面上项目（30770770）;国家人事部留学归国人员科研资助项目（200748）;山西省高校科技研究开发项目（2007123）

摘　　要：目的 观察及探讨抑郁症经治疗前后的P300指标变化情况.方法 收集符合DSM-Ⅳ诊断标准的99例首次发病的抑郁症患者作为病例组,及100例相匹配的对照组.分别于治疗前和治疗后6周,12周,24周进行认知电位检测.t检验分析组间各指标的差异,重复测量方差分析P300指标纵向变化.结果 ①治疗前病例组N2、P3、P2-N2潜伏期较正常对照延长（P＜0.01）;N2-P3潜伏期较对照组缩短（P＜0.01）;病例组N2、P3、N2-P3波幅较正常对照组减低（P＜0.05）;P2-N2波幅较对照组增大（P＜0.01）.②重复测量方差分析结果 ：治疗期间病例组N2、P3、P2-N2潜伏期有下降的趋势,N2-P3潜伏期及P3、N2-P3波幅有上升趋势,但均差异无显著性（P＞0.05）.配对t检验：治疗24周后与治疗前相比：P3、N2-P3波幅增高（P＜0.01）.治疗24周后与正常对照组相比,P300潜伏期或波幅等各指标均数均差异无显著性（P＞0.05）.结论 抑郁症患者经抗抑郁急性期治疗后P300波幅及潜伏期等指标趋向于部分正常,而长期治疗后的变化规律尚不清楚.Objective To explore the event-related potentials （ERPs） P300 is changeable or not before and after treatment. Methods 99 cases of patients with first onset of depression diagnosed by DSM-Ⅳ as case group,and 100 cases matched with patients as control group were collected. P300 of two groups were obtained before and after treatment for 6 weeks,12 weeks,24 weeks. T test was used to analysis the difference of indicators of P300 among groups; repeated measure analysis of variance was used to analysis the longitudinal changes. Results shorter latency of N2-P3 （ （P 〈 0.01 ）; and lower amplitude of N2, P3, N2-P3 （P 〈 0. 05 ）, higher amplitude of P2-tency and a upward one in N2-P3 latency in the four periods; a upward trend could also be found in P3, N2-P3 amplitude, but there were no statistical differences（P 〉 0. 05 ）. The results of paired-samples t test： P3, N2-P3 amplitude in case group were higher after treatment for 6 weeks than before, the difference was significant （P 〈 0.01 ）; no significant results were found in P300 latency or amplitude between the 62 cases of depression after treatment for 24 weeks and the 65 normal controls selected （P 〉 0. 05 ）. Conclusion P300 latencies and amplitudes tend to be partly recovered after the acute treatment in patients with depression, but after the long-term therapy not clear.

关 键 词：抑郁症 事件相关电位 西酞普兰 

分 类 号：R749.4[医药卫生—神经病学与精神病学]