重组人干扰素-α2b治疗宫颈上皮内瘤变疗效观察  

Effect of recombinant human interferon α-2b on cervical intraepithelial neoplasia

作　　者：王君[1] 周魏军[1] 郑冬梅[1] 贺彩军[1] 王娟[1] 贾云[1] 黄彩虹[1] 

机构地区：[1]解放军第211医院,黑龙江哈尔滨150080

出　　处：《西部医学》2010年第11期1995-1996,1999,共3页Medical Journal of West China

摘　　要：目的探讨干扰素治疗宫颈上皮内瘤变(CINI)的疗效,为预防宫颈癌有效措施提供科学依据。方法选择在我院门诊阴道镜下活检确诊CINI患者156例,根据自愿选择原则分为治疗组96例,对照组60例,治疗组于非月经期阴道上药干扰素,6个月后复查阴道镜。结果①治疗组CINI治愈率71.9%,对照组自愈率31.7%,治疗组治愈率高于对照组,差异有显著性(P<0.01)。②宫颈分泌物人乳头瘤病毒(HPV)检测,治疗组转阴率68.7%,对照组21.1%,差异有显著性(P<0.01)。结论干扰素栓用于低度CIN的治疗可增加其逆转率,对CINI合并HPV感染疗效显著,可阻断其向更高一级发展。Objective To explore the effect of interferon on cervical intraepithelial neoplasia（CINI）.Methods 156 patients with CINI were divided into treatment group（96 cases） and control group（60 cases）.The treatment group was treated with interferon on non-menstrual phase.Results The cure rates of treatment group and control group were 71.9% and 31.7%（P0.01）,respectively.The negative rates of cervical secretions of human papillomavirus（HPV） test of treatment group and control group were 68.7% and（P0.01）,respectively.Conclusion It is effective to treat CIN with interferon.

关 键 词：宫颈上皮内瘤样病变 干扰素 人乳头状瘤病毒 

分 类 号：R737.33[医药卫生—肿瘤]