树突状细胞免疫治疗用于局部进展性肾癌根治术患者效果观察  

Observation on the effects of dendritic cell immunotherapy to patients performed radical nephrectomy of locally advanced renal cell carcinoma

作　　者：李顺[1] 张毅[2] 李博[1] 赵庆利[1] 李青[1] 

机构地区：[1]山东大学附属千佛山医院,济南250014 [2]济南市第一人民医院

出　　处：《山东医药》2010年第39期11-13,共3页Shandong Medical Journal

基　　金：山东省自然科学基金资助项目(Y2007C166)

摘　　要：目的进一步提高局部进展性肾癌的治疗效果。方法将57例局部进展性肾癌患者随机分为观察组27例、对照组30例。两组均行肾癌根治术。观察组术后2周行树突状细胞(DC)免疫治疗。检测两组术前及术后8周外周血T淋巴细胞亚群CD4+、CD8+水平及CD4+/CD8+值,观察不良反应;随访1a、3a生存率。结果观察组术后CD4+水平及CD4+/CD8+明显高于术前,CD8+明显低于术前,P<0.05;对照组上述指标与术前比较无显著差异。观察组未出现明显不良反应。观察组3a生存率明显高于对照组,P<0.05。结论局部进展性肾癌患者根治术后DC免疫治疗可增强免疫功能,延长生存时间。Objective To improve the clinical treatment effect of locally advanced renal cell carcinoma. Methods Fifty-seven patients with renal cell carcinoma were were randomly divided into observation group（ 27 cases） and control group（ 30 cases） . Radical nephrectomy were performed in both groups. Dendritic cells （ DC） were used in observation group 2 weeks after operation. The T-lymphocyte subsets CD4、CD8,the ratio of CD4 /CD8 were tested before and 8 weeks after operation,adverse reaction were observed; 1 year,3 years survival rate were followed up. Results T-lymphocyte subsets of CD4 and CD4 /CD8 in observation group increased after operation,and CD8 decreased significantly,P 0. 05; no changes were found in the control group. No adverse reaction were observed in the observation group. The 3 year survival rate in the observation group was obviously higher than that in the control group,P 0. 05. Conclusion DC immunotherapy to patients performed radical nephrectomy of locally advanced renal cell carcinoma can enhance immune function,prolong the survival time.

关 键 词：树突状细胞 免疫治疗 肾细胞癌 局部进展性 

分 类 号：R737.11[医药卫生—肿瘤]