甘草酸二铵脂质复合物对脂肪肝大鼠的防治作用  

EFFECT OF DIAMMONIUM GLYCYRRHIZINATE PHOSPHATIDYLCHOLINE COMPLEX IN THE PREVENTION AND TREATMENT OF RATS WITH FATTY LIVER DISEASE

作　　者：张国顺[1] 王玉兰[1] 尚华[2] 张超[1] 李玉林[1] 李志婷[1] 徐晓平[1] 田国华[1] 

机构地区：[1]华北煤炭医学院附属医院消化内科,唐山063000 [2]唐山市传染病院

出　　处：《现代预防医学》2010年第21期4022-4024,共3页Modern Preventive Medicine

基　　金：唐山市科技攻关项目(081302010)

摘　　要：[目的]探讨甘草酸二铵脂质复合物对大鼠脂肪肝的防治作用。[方法]采用高浓度酒精灌胃配合高脂饲料饲养制备大鼠脂肪肝模型,同时给予不同剂量甘草酸二铵脂质复合物治疗,以二甲双胍为对照,通过检测血清肝酶谱、肝组织匀浆甘油三酯含量和肝脏组织学变化,观察不同剂量甘草酸二铵脂质复合物对脂肪肝的防治作用。[结果]模型组大鼠肝脏出现明显的脂肪变性,肝酶活性(ALP、GGT)、血脂和肝组织甘油三酯含量升高;甘草酸二铵脂质复合物各剂量组肝细胞脂肪变显著减轻,肝酶活性(ALP、GGT)、血脂和肝组织甘油三酯含量较模型组显著下降,二甲双胍组肝组织甘油三酯含量较模型组下降。[结论]甘草酸二铵脂质复合物对脂肪肝具有良好的防治作用。[Objective] To investigate the preventive and therapeutic effect of preparation of diammonium glycyrrhizinate phosphatidylcholine complex on the rats with fatty liver disease（FLD）.[Methods] The fatty liver model was established by feeding with high caloric laboratory chaw and alcohol.Sixty male Wistar rats were randomized into 6 groups,i.e.a normal control group,a model group,three diammonium glycyrrhizinate phosphatidylcholine complex groups treated with different concentrations and a metformin group.All the animals were killed after treatment for 8 weeks.The activities of alkaline phosphatase and gamma glutamyl transferase,blood lipid,liver triglycerin and pathological changes in all groups were assayed.[Results] The activities of alkaline phosphatase and gamma glutamyl transferase,blood lipid,liver triglycerin of model group increased significantly;liver histology showed mild to moderate steatosis.Those indexes of diammonium glycyrrhizinate phosphatidylcholine compound groups were significantly lower than those of model group.The hepatic steatosis was also improved.Liver triglycerin of metformin group was significantly reduced.[Conclusion] Diammonium glycyrrhizinate phosphatidylcholine complex is effective in the prevention and therapy of FLD rats.

关 键 词：甘草酸二铵脂质复合物 大鼠 脂肪肝 防治 

分 类 号：R575.5[医药卫生—消化系统]