经导管前列腺素E1脂微球载体保护肝损伤的实验研究  

Study on Prostaglandin E1's Protective Effect on the Hepatic Tissue Damaged by Hepatic Artery Embolism

作　　者：罗芙蓉[1] 郑尚飞 曹海利[1] 崔立明[1] 王凯冰[1] 徐伟[1] 白彬[1] 

机构地区：[1]哈尔滨医科大学附属第二医院介入科,黑龙江150086 [2]宁波市鄞州人民医院放射科,浙江315100

出　　处：《当代医学》2010年第29期601-604,共4页Contemporary Medicine

基　　金：国家中医药管理局中医药科学技术研究专项课题;编号0607ZP14

摘　　要：目的探讨前列腺素E1对肝动脉栓塞后肝损伤的保护作用。方法将实验动物分为:A组(空白组)、B组(单纯碘化油肝动脉栓塞组)、C组(碘化油联合前列腺素E1肝动脉栓塞组),对比观察各组实验动物的组织病理学、血液生化学改变。结果 B组犬肝损伤明显,丙氨酸氨基转移酶(Alanine aminotransferase,ALT)、天冬氨酸转移酶(Aspartate aminotransferase,AST)和乳酸脱氢酶(Lactate dehydrogenase,LDH)等生化指标明显升高,组织病理学观察可见栓塞区周围炎性细胞浸润,肝细胞肿胀、变性,散在碎片状坏死。C组犬肝损伤相对轻微,相关生化指标早期升高,然后明显下降,组织病理学观察肝细胞以细胞变性为主,少量点状坏死,肝栓塞区周围炎性细胞浸润。结论前列腺素E1可有效预防肝动脉栓塞所致肝损伤。Objective To investigate into the protective effect of prostaglandin E1 on the dogs＇ hepatic tissue damaged by hepatic artery embolism.Methods 1.The experimental animals were randomly divided into three groups.The dogs of Group A were injected physiological saline into hepatic artery.The dogs of Group B were injected simple lipiodol into hepatic artery.The dogs of Group C were injected lipiodol combined prostaglandin E1 into hepatic artery.2.Remark on the applied value of prostaglandin E1＇s protection and cure in liver injury resulted from TACE.Results The experimental results were that in Group B obvious hepatic injury was observed in the liver of dogs,such indexes as ALT,AST and LDH,etc.,were increased remarkably,and piecemeal necrosis of liver cell were observed in histopathology.In Group C,liver cell degeneration was observed in the dogs＇ liver,but there was no obvious piecemeal necrosis in the liver lobule.Such biochemical indexes as ALT,AST,and LDH,etc.,were increased early.Conclusion Prostaglandin E1 can effectively prevent injury to normal liver tissue from hepatic artery embolism.

关 键 词：介入 肝动脉栓塞 肝损伤 前列腺素E1 

分 类 号：R575[医药卫生—消化系统]