不同部位胃肠道间质瘤的预后分析  

Prognostic analysis of gastrointestinal stromal tumor in different parts of gastrointestinal tract

作　　者：成超[1] 卢晓明[1] 王国斌[1] 童强[1] 马敬伟[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院胃肠外科中心,武汉430022

出　　处：《临床外科杂志》2010年第10期662-664,共3页Journal of Clinical Surgery

摘　　要：目的探讨不同部位胃肠道间质瘤患者的预后差异及其影响因素。方法对66例胃肠道间质瘤患者进行回顾性分析。采用Kaplan—Meier法对患者无复发生存率进行比较分析，分别采用单因素及多因素分析对影响预后的因素进行评估。结果Kaplan—Meier分析表明十二指肠间质瘤患者术后3年无复发生存率明显低于其他部位间质瘤患者（P=0．002）。单因素分析显示肿瘤大小、原发部位、核分裂数目、临床症状均与患者预后显著相关（P〈0．05）；多因素分析表明肿瘤大小、原发部位、核分裂数目为胃肠道间质瘤预后的有效预测指标。结论不同部位胃肠道间质瘤的3年无复发生存率之间存在显著性差异，其中十二指肠间质瘤的预后最差。肿瘤大小、原发部位、核分裂数目是胃肠道间质瘤预后的独立预测指标。Objective To investigate the difference of survival for patients with gastrointestinal stromal tumor （GIST） and the prognostic factors. Methods The clinical data of 66 patients with GIST admitted in Union Hospital （Wuhan） from May 2002 to August 2006 were analyzed retrospectively. The recurrence -free survival （RFS） rates of GIST patients were calculated by the Kaplan -Meier method and compared using the log - rank test. Furthermore, the potentially prognostic factors were investigated by univariate and multivariate analysis, respectively. Results Kaplan - Meier analysis showed that the 3 - year RFS rate of patients with duodenal GIST was significantly poorer than that of patients with nonduode- nal GIST （ P = 0. 002 ）. Univariate analysis revealed that tumor size, tumor location, mitotic index and symptom were significantly correlated with prognosis （ P 〈 0.05 ）. Multivariate analysis indicated that tumor size ,tumor location and mitotic index were independent prognostic factors for GISTs. Conclusion The differences of 3 - year RFS rate were significant in different parts of gastrointestinal tract, and the 3 - year RFS rate of duodenal GIST was worst among the three groups. Tumor size, tumor location and mitotic index were independent prognostic factors for GIST.

关 键 词：胃肠道间质瘤 生存分析 预后 

分 类 号：R735[医药卫生—肿瘤]