弱视儿童治疗前后PR-VEPP_(100)波变化探讨  

Study on change of PR-VEP P100 wave before and after treatment in amblyopia children

作　　者：徐国兴[1,2,3] 洪金针[1,2,3] 林玲[1,2,3] 林发森[1,2,3] 何青[1,2,3] 侯丽枫[1,2,3] 刘宝英[1,2,3] 

机构地区：[1]福建医科大学第一医院眼科 [2]福建省眼科研究所 [3]福建医大卫生系

出　　处：《中国实用眼科杂志》1999年第4期237-238,共2页Chinese Journal of Practical Ophthalmology

摘　　要：为了进一步评价全视野图形反转刺激的弱视治疗前后与正常儿童的图形反转视诱发电位Ｐ１００波变化，随机选择我院２９例（５８眼）治疗前后弱视儿童及３０例正常儿童，两组年龄均在４～１２岁，采用Ｎｏｍａｄｌｅ电生理仪进行电生理检查。结果：弱视组ＰＲ—ＶＥＰＰ１００振幅明显低于正常对照组Ｐ＜０．０１（１１．１６±６．７４μｖｎ＝５６ｖｓ１６．７８±５．５５μｖｎ＝６０）潜伏期比正常对照组明显延长Ｐ＜０．０１（１１０．３９±１０．０１ｍｇｎ＝５６ｖｓ１０１．８１±４．３８ｍｓｎ＝６０）。弱视经治疗视力达基本正常时的ＰＲ—ＶＥＰＰ１００潜伏期与治疗前的Ｐ１００潜伏期比较有显著差异（Ｐ＜０．０１）。结论：弱视儿童的ＰＲ—ＶＥＰＰ１００振幅降低，Ｐ１００潜伏期延长。弱视儿童视力降低同时有ＰＲ—ＶＥＰ参数异常的趋势。弱视儿童的ＰＲ—ＶＥＰＰ１００潜伏期经治疗视力达基本正常时Ｐ１００潜伏期可以逆转。We further evaluated Visual evoked Potential (VEP) in amblyopia and normal children with full field pattern reversal stimulation.Methods:29 children (58eyes) with amblyopia were randombly selected from our clinic and 30 normal Children both aged 4～12 were electrophyologically examined by using Nomadle model.Results:In the amblyopia group PR-VEP P100 amplitude was aignificantly lower than control group (11 16±6 7uV,n=56,vs 16 78±5 55uV,n=60).latency was signifcantly (P<0 01) prolonged in amblyopia eyes Compared with control eyes (110 39±10 01ms,n=56 vs 101 31±4 33ms,n=60),Conclusion:Our results indicate that the decrease of VEP amplitude and prolonged latency are well in agreement with other reports,while reduced visual acuity in children with amlbyopia tends to aggravate VEP parameter.The latency of PR-VEP P100 in amblyopia children can be reyerse after treatment visual acuity turn to normal.

关 键 词：图形反转 视觉诱发电位 弱视 儿童 

分 类 号：R777.440.5[医药卫生—眼科] R770.43[医药卫生—临床医学]