检索规则说明:AND代表“并且”;OR代表“或者”;NOT代表“不包含”;(注意必须大写,运算符两边需空一格)
检 索 范 例 :范例一: (K=图书馆学 OR K=情报学) AND A=范并思 范例二:J=计算机应用与软件 AND (U=C++ OR U=Basic) NOT M=Visual
作 者:栾天燕[1] 尹宝玉[1] 韩强[1] 李京云[1]
出 处:《肿瘤学杂志》2010年第10期802-804,共3页Journal of Chinese Oncology
摘 要:[目的]探讨多西紫杉醇联合奥沙利铂治疗中晚期食管癌的疗效及毒副反应。[方法]32例经病理证实中晚期食管癌患者,多西紫杉醇60~75mg/m2,静脉滴注,d1,70岁以上老年患者35~40mg/m2,静脉滴注,d1、8;奥沙利铂100mg/m2,静脉滴注,d2。21d为1个周期。[结果]32例患者中,CR1例(3.13%),PR12例(37.50%),SD9例(28.13%),PD10例(31.25%),总有效率为40.63%,临床获益率为68.75%。其中初治患者有效率44.44%,复治患者有效率35.71%。主要毒副反应为骨髓抑制和神经感觉异常,非血液学毒性反应较轻,无化疗相关死亡。[结论]多西紫杉醇联合奥沙利铂治疗中晚期食管癌疗效较好,且毒副反应可耐受。[Purpose] To investigate the response and toxicity of docetaxel(TXT) combined with oxali- platin(OXA) in the treatment of advanced esophageal cancer. [Methods] Thirty-two cases with advanced esophageal cancer pathologically proved were enrolled. All patients received docetaxel 60~ 75mg/m2, iv gtt, d1; except patients over 70 years old received docetaxel 35~40mg/m2, iv gtt, d1,8. Oxaliplatin 100mg/m2, iv gtt, d2. Twenty-one days as a cycle. [Results] Of 32 cases, 1 case(3.13%) was CR; 12 (37.50%), PR; 9 (28.13%), SD; and 10 (31.25%), PD. The overall response rate was 40.63%, clinical benefit rate was 68.75%. The response rate in initial treatment group and in recurrence group was 44.44% and 35.71%, respectively. The main toxicity was myelosuppression and nerve toxicity,non-hematic toxicity was mild, no treatment-related death occurred. [Conclusion]Do-cetaxel combined with oxaliplatin is effective and tolerable for advanced esophageal cancer.
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在链接到云南高校图书馆文献保障联盟下载...
云南高校图书馆联盟文献共享服务平台 版权所有©
您的IP:216.73.216.229