AIF与凋亡的关系及其相关的结直肠癌治疗研究  

The relationship between AIF and apoptosis and colorectal cancer related to AIF

作　　者：李靓[1] 李洋[1] 

机构地区：[1]重庆医科大学附属第二医院普外科,重庆400010

出　　处：《国际外科学杂志》2010年第11期753-756,共4页International Journal of Surgery

基　　金：重庆市卫生局医学科研项目（No.2008-2-227）

摘　　要：许多促凋亡信号转导分子作用于线粒体，引发线粒体外膜通透性的改变，从而引发潜在的促凋亡蛋白的释放。其中较为重要的一个为凋亡诱导因子（AIF）。当收到致命信号后，由线粒体释放，并迅速从细胞质移位到细胞核里结合DNA并引起不依赖天冬半胱氨酸蛋白激酶（Caspase）的染色质凝集，从而导致细胞凋亡。AIF已逐步被发现在一些恶性癌细胞（如结直肠癌细胞）中具有重要作用，特别是它在细胞凋亡中的调控作用。最近一些研究成果表明，通过影响AIF释放或表达来诱导细胞凋亡已成为结直肠癌治疗的新的研究方向。Numerous pro-apoptotic signal transducing molecules act on mitochondria and provoke the permeabilization of the outer mitochoudrial membrane, thereby triggering the release of pro-apoptotic proteins potentially. One of them is much important,which called apoptosis inducing factor（AIF）. Upon lethal signaling,AIF released from mitochondria, which translocates, via the cytosol to the nucleus,where it binds to DNA and provokes Caspase-independent chromatin condensation and leading to apoptosis. It has been found gradually that AIF has impotant effect in some malignant cancer cells （such as colorectal carcinoma cell）, especially its regnlation effect in cell death. Recently some of researches indicate that inducing cell apoptosis by effecting on the releasing or expressing of AIF, has been a new research direction of colorectal carcinoma therapy.

关 键 词：凋亡诱导因子 细胞凋亡 结直肠肿瘤 线粒体 天冬半胱氨酸蛋白激酶 

分 类 号：R735.3[医药卫生—肿瘤]