人类胰腺癌表达谱研究  

Study of expression profile in human pancreatic cancer

作　　者：何航[1] 傅德良[1] 

机构地区：[1]复旦大学胰腺病研究所,复旦大学附属华山医院普外科,上海200040

出　　处：《国际外科学杂志》2010年第11期769-774,共6页International Journal of Surgery

基　　金：上海市优秀学科带头人计划（No.08XD14010）;卫生部临床学科重点项目（No.2007-2009）

摘　　要：胰腺癌是一类发病隐匿、侵袭率高、早期转移的恶性肿瘤，其独特的生物学行为一直以来是肿瘤研究的热点。本文通过回顾至今为止有关胰腺癌组织表达谱的研究，以总结在胰腺癌表达谱研究领域的成果、挑战和发展方向，并认为以基因表达分析为突破点，在理想的胰腺癌动物模型上进行有关胰腺癌发生发展机制的研究，将有助于胰腺癌的综合诊治和改善胰腺癌患者的预后。Pancreatic adenocarcinoma is a severe-invasive, early-metastasis and malignant neoplasm with latent pathogenesis, while its biological behaviors are the highlight of current tumor study. In present study, through reviewing the studies related to expression profile of pancreatic cancer up to now. This artical summarized the achievement, challenge and trend of development of expression profile in pancreatic cancer. In conclusion, exploring the mechanism of carcinogenesis and development of pancreatic cancer based on the breakthrough of expression-profiling studies and establishing ideal models of pancreatic cancer, will promote systemic diagnosis and treatments of pancreatic cancer and do favor to the prognosis of the patients.

关 键 词：胰腺肿瘤 表达谱 人类 

分 类 号：R735.9[医药卫生—肿瘤]