美施康定对癌症疼痛的镇痛效果  

MANAGING CANCER PAIN WITH MORPHINE SULPHATE CONTROLLED-RELEASE TABLETS

作　　者：李平[1] 庄承海[1] 廖倚萍[1] 郑坚[1] 

机构地区：[1]暨南大学医学院附一院肿瘤科

出　　处：《中国药物依赖性杂志》1999年第2期135-137,共3页Chinese Journal of Drug Dependence

摘　　要：本组５４例重度癌痛晚期病人，给予口服美施康定３０－９０ｍｇ，每１２ｈ一次治疗，有效率９６．３％（５２／５４），完全缓解率达８７．０％（４７／５４）。治疗中同时应用化疗及放疗，从病因上消除癌症所致的疼痛，部分病人因疼痛缓解而停用美施康定。应用美施康定其主要的副作用为便秘、恶心、呕吐、嗜睡等，治疗剂量未出现呼吸抑制及成瘾性发生。美施康定对骨痛、内脏痛、软组织浸润痛的镇痛效果较好，对神经痛效果欠佳，对这类疼痛应联合使用三环类药物，抗惊厥类及皮质类固醇等治疗。美施康定口服给药后，其起效时间及作用时间存在着个体差异，应遵循个体化原则增加剂量及用药间隙时间。Fifty-four patients with severe cancer pain were treated with morphine sulphate controlled-release tablets(MS Contin), 30-90 mg each time,po, twice daily. The total response rate and complete remission rate were 96.3%(52/54) and 87%(47/54) respectively. Chemotherapy and radiotherapy were given stimutaneously. Some of the patients whose pain released stopped using MS Contin. The main clinical side-effects were constipation, nausea, vomiting, somnolence etc. No opium drug addiction and respiratory restraint were found within treatment dosage.

关 键 词：癌痛 美施康定 镇痛 

分 类 号：R730.53[医药卫生—肿瘤] R441.1[医药卫生—临床医学]