MPTP小鼠黑质神经元细胞凋亡及Deprenyl抗凋亡作用的研究  

The study of the apoptosis of dopaminergic neurons and the antiopoptotic effect of deprenyl in MPTP-mice

作　　者：匡永锋[1] 童启进[2] 王德新[2] 赵伟秦[2] 

机构地区：[1]广州医学院附属市二人民医院神经内科,510150 [2]首都医科大学附属北京友谊医院神经内科

出　　处：《脑与神经疾病杂志》1999年第3期133-135,共3页Journal of Brain and Nervous Diseases

摘　　要：目的：观察MPTP-Parkinsonism小鼠多巴胺能神经元细胞凋亡及Deprenyl抗凋亡作用；方法：应用TUNEL染色、TH、BCL－2免疫组化染色、TUNEL／TH双标染色和电镜技术观察多巴胺能神经元凋亡及Deprenyl抗凋亡作用；结果：模型鼠脑黑质内有多巴胺能神经元凋亡．而Deprenyl可阻止这种神经元凋亡；结论：1．模型中多巴胺能神经元的丢失可能是通过细胞凋亡机制实现的；2．Deprenyl可能部分阻止多巴胺能神经元凋亡。Object: TO investgate the apoptosis of dopaminergic neurons and the antiopoptotic effect of deprenyl in MPTP-Parkinsonia mice; Method: To examine the apoptosis of dopaminergic neurons and the antiopoptotic effect of deprenyl by using TH and BCL-2 stains, TUNEL stain and TUNEL/TH double stainings. Result: There are apoptosis of dopaminergic nuerons, and deprenyl can prevent apoptosis of dopaminergic neurons in the MPTP-Parkinsonial mice. Conclusion: 1. The loss of nigral dopaminergic neurons may occur via active apoptotic mechanism in MPTP-Parkinsonian mice. 2. Deprenyl can prevent apoptosis of dopaminergic neurons in MPTP-Parkinsonian mice.

关 键 词：四氢吡啶 细胞凋亡 DEPRENYL 震颤麻醉 治疗 

分 类 号：R742.5[医药卫生—神经病学与精神病学]