反社会人格障碍早期临床风险概念化及操作化研究  

Separate conceptualization and operationalization on early clinical risks associated with antisocial personality disorder

作　　者：石振宇[1,2] Jean-Francois Bureau M.Ann Easterbrooks 赵旭东[2] Karlen Lyons-Ruth 

机构地区：[1]哈佛大学医学院精神医学系,美国麻省02138 [2]同济大学医学院,上海200092 [3]渥太华大学心理学院,加拿大渥太华02140 [4]塔夫斯大学儿童系,美国麻省02143

出　　处：《同济大学学报（医学版）》2010年第5期63-66,共4页Journal of Tongji University(Medical Science)

基　　金：美国国立精神卫生研究所资助项目(R01MH35122;R01MH06030)

摘　　要：目的探索早期临床风险是否构成反社会人格障碍罹患的危险因素及早期临床风险和儿童虐待的关系。方法用回顾性的自我报告虐待法和儿童保护机构虐待纪录获得法分别测量了120例早期成年人儿童虐待和早期临床风险。以反社会人格障碍作为结果变量,进行阶层回归分析、统计学中介分析和相关分析。结果儿童虐待和早期临床风险相关(效应强度0.38,P=0.007),但儿童虐待不能中介早期临床风险的作用。早期临床风险(症状Β=0.28P=0.03,诊断Wald=5.83P=0.01)和儿童虐待(症状Β=0.22,P=0.03;诊断Wald=2.98,P=0.04)分别独立地和反社会人格障碍有关。结论儿童虐待和早期临床风险都是反社会人格障碍的危险因素,需要对早期临床风险进行独立概念化和操作化。Objective To investigate the relationship between childhood abuse and early clinical risk which both were associated with antisocial personality disorder.Methods Antisocial personality disorder among 120 young adults were determined by retrospective self-report for childhood abuse,Child Protective Service records for maltreatment at infancy and Structured Clinical Interview-II（SCID-II）.Hierarchical regression and mediation were employed to analyze possible relationships.Results Early clinical risk on antisocial personality disorder was correlated with childhood abuse（effect size 0.38,P=0.007） but was not caused by childhood abuse.Two indicators were associated with antisocial personality disorder including early clinical risk（symptoms Β=0.28 P=0.03,diagnosis Wald=5.83 P=0.01） and childhood abuse（symptoms Β=0.22 P=0.03,diagnosis Wald=2.98 P=0.04）.Conclusion Both childhood abuse and early clinical risk are risk factors for the etiology of antisocial personality disorder.Early clinical risk needs to be conceptualized and operation-alized separately from conventional childhood abuse.

关 键 词：反社会人格障碍 儿童虐待 早期临床风险 

分 类 号：R749[医药卫生—神经病学与精神病学]