18例染色体异常核型女性供精人工授精结局分析  

Retrospective Analysis of the Relationship between Chromosomal Abnormalities of 18 Females and the Outcomes of Artificial Insemination

作　　者：相文佩[1] 庞文娟[1] 刘丽君[1] 李红钢[1] 胡廉[1] 廖爱华[1] 

机构地区：[1]华中科技大学同济医学院计划生育研究所/生殖医学中心,武汉430030

出　　处：《生殖与避孕》2010年第10期713-717,共5页Reproduction and Contraception

摘　　要：目的:探讨染色体核型异常对人工授精妊娠结局的影响。方法:回顾性分析因其配偶为特发性不育而接受供精人工授精(AID)治疗的1 300例正常女性,外周血淋巴细胞染色体G显带核型异常与供精人工授精治疗结局的关系。结果:检出异常核型18例(染色体异常发生率1.38%),包括平衡易位和罗伯逊易位各1例(0.08%),9号染色体臂间倒位9例(0.69%),其他7例(0.54%)。18例染色体核型异常患者术前检查显示其排卵正常,输卵管通畅,子宫及双侧附件均未见明显异常。AID治疗结果8例未孕,其中罗伯逊易位1例、臂间倒位3例、其他4例,10例妊娠成功。结论:因男性特发性不育患者,特别是进行辅助生殖治疗多个周期后仍未受孕的夫妇,对女方进行细胞遗传学检查是非常必要的。Objective： To investigate the effect of abnormal chromosomal karyotype on pregnancy outcome.Methods： The blood samples of 1 300 cases of women whose husbands are infertile were examined by G banding cytogenetic analysis and they were treated by artificial insemination with donor sperm.The relationship between chromosomal aberrations and the outcomes of artificial insemination was retrospectively analyzed.Results： Eighteen abnormal chromosomal karyotypes were found among 1 300 participants（1.38%）,including 1 balanced translocation（0.08%）,1 Robertsonian translocation（0.08%）,9 pericentric inversions of chromosome 9（0.69%）,7 others（0.54%）.Among 18 cases with normal ovulations and passable oviduct treated by artificial insemination with donor sperm（AID） at the right time,10 were pregnant and 8 were not.Conclusion： It is very important for the women whose husbands are infertile,especially still infertile after the treatment of several cycles of assisted reproduction to do the prenatal genetic investigation.

关 键 词：染色体核型异常 供精人工授精 臂间倒位 

分 类 号：R714.8[医药卫生—妇产科学]