老年抑郁症患者失眠与血浆褪黑素水平的关系  

Relationship of the Levels of Melatonin and Insomnia in Senile Depressive Patients

作　　者：代娟[1] 李恒芬[2] 曹素霞[2] 谢正[3] 

机构地区：[1]广东省中山市人民医院(中山大学附属中山医院)心理科,中国528403 [2]郑州大学第一附属医院心理科 [3]河南省中医学院第一附属医院

出　　处：《中国健康心理学杂志》2010年第11期1285-1287,共3页China Journal of Health Psychology

摘　　要：目的老年抑郁症患者睡眠障碍与血浆褪黑素水平的关系。方法取54例老年抑郁症患者(研究组),50例健康体检的退休人员(对照组)肘静脉血3mL,采用放射免疫法对血浆中的褪黑素水平进行测定。结果老年抑郁症患者血浆褪黑素水平与健康对照组差异无统计学意义(t=1.719,P=0.088),老年抑郁症患者中睡眠障碍组血浆褪黑素水平与正常对照组的差异有统计学意义(t=2.35,P=0.008),睡眠障碍中的早醒组血浆褪黑素水平明显低于正常对照组(t=2.775,P=0.006)。研究组中睡眠节律紊乱的严重程度与血浆M T水平呈负相关(r=-2.35,P=0.008)。结论老年抑郁症患者有睡眠障碍时血浆褪黑素水平明显下降,褪黑素联合SSR I类抗抑郁剂可用于老年抑郁症的治疗,能有效改善其失眠症状,安全性高,副作用小。Objective To investigate the relationship between the levels of melatonin and insomnia in senile depressive patients.Methods Fifty-four senile depressive patients（study group）,fifty healthy retirement（contral group）were taken cubitalvenous blood samples 3mL,radioimmunoassay was conducted to determine the serum melatonin levels.Results There was no significant difference between the study group and the contral group（t=1.719,P=0.088）.The melatonin levels of senile depressive patients with insomnia was significantly lower than control group（t=2.35,P=0.008）.The melatonoin levels of senile depressive patients with early awakening was significantly lower than control group（t=2.775,P=0.006）.There was negative correlation between the melatonoin levels and the severity of senile depressive patients with insomnia（r=-2.35,P=0.008）.Conclusion The melatonin levels of senile depressive patients with insomnia are reduced.The SSRI-antidepressant combined with melatonin treating the senile depressive patients can ameliorate symptom.It is safe and reliable.

关 键 词：老年抑郁 褪黑素 睡眠障碍 

分 类 号：R749.4[医药卫生—神经病学与精神病学]