膀胱移行细胞癌中钙粘素E及α连接素的表达及临床意义  

E cadherin and α catenin expressions in bladder transitional cell carcinoma

作　　者：武玉东[1,2] 魏金星[1,2] 杨俊福[1,2] 马腾骧 吴海 吴长利[1,2] 

机构地区：[1]河南医科大学第一附属医院泌尿外科 [2]天津市泌尿外科研究所

出　　处：《中华泌尿外科杂志》1999年第5期279-281,共3页Chinese Journal of Urology

摘　　要：目的探讨钙粘素Ｅ（Ｅｃａｄ）和α连接素（αｃａｔ）在膀胱移行细胞癌中的表达及临床意义。方法应用免疫组化方法检测５９例膀胱移行细胞癌中Ｅｃａｄ和αｃａｔ的表达。结果５９例中Ｅｃａｄ及αｃａｔ的异常表达率分别为５８％和６６％，其中５２例肿瘤组织（８８％）二者同时正常或异常表达，二者表达之间具有显著相关性（Ｐ＜０．０１）。Ｅｃａｄ及αｃａｔ在Ⅰ、Ⅱ、Ⅲ级肿瘤中的异常表达率分别为１８％，４７％，７９％和１８％，５８％，９０％；在Ｔｉｓ～Ｔ１，Ｔ２～４肿瘤中的异常表达率分别为１６％，７８％和２６％，８５％。二者的异常表达率在肿瘤的病理分级和临床分期等方面差异具有显著性（Ｐ＜０．０５）。结论Ｅｃａｄ和αｃａｔ的异常表达在膀胱肿瘤的恶性进展过程中起重要作用，二者均可作为判断肿瘤恶性程度及预后的指标。Objective To study the expression and the clinical significance of E cadherin (E cad) and α catenin(α cat) in bladder transitional cell carcinoma (BTCC). Methods Immunohistochemical method was used to detect E cad and α cat expressions in 59 cases of bladder transitional cell carcinoma. Results The abnormal expression rate of E cad and α cat was 58% and 66% respectively.E cad and α cat expression was concomitantly either normal or abnormal in 88% of tumors,the correlation between E cad and α cat expression being highly significant ( P <0.01).The abnormal expression rates of E cad and α cat were 18%,47%,79%and 18%,58%,90% in G 1,G 2,G 3 of bladder transitianal cell carcinoma respectively and were 16%,78% and 26%,85% in Tis～T 1,T 2～4 tumors.Both the gene expressions were related to the tumor grade,clinical stage and prognosis ( P <0.05). Conclusions Aberrant expression of E cad and α cat played an important role in the malignant progression of BTCC,and could be used as a marker of malignant potential and prognosis of BTCC.

关 键 词：膀胱肿瘤 免疫组织化学 移动细胞癌 钙粘素E 

分 类 号：R737.14[医药卫生—肿瘤]