2-羟基-1-萘酚醛缩2-氨基苯并噻唑铜配合物的合成及其与DNA作用的光谱研究  

Synthesis of Schiff Base Condensed from 2-Hydroxy-1-Naphthalde-Hyde with 2-Amino-Benzothiazole and Its Copper Complexes and Spectral Study on Its Interaction with ct-DNA

作　　者：杨欢春[1,2] 杨天林[1] 王丽娟[1] 

机构地区：[1]宁夏大学能源化工重点实验室 [2]宁夏疾病预防控制中心

出　　处：《光谱实验室》2010年第6期2124-2129,共6页Chinese Journal of Spectroscopy Laboratory

基　　金：教育部科学基金重点项目(208159);宁夏高校科学研究基金资助项目

摘　　要：合成了2-羟基-1-萘酚醛缩2-氨基苯并噻唑铜配合物,通过IR、UV、元素分析、摩尔电导及热分析,对此化合物进行了结构表征。在pH 7.22的Tris-HCl缓冲溶液中,采用紫外光谱、荧光光谱和粘度法研究了2-羟基-1-萘酚醛缩2-氨基苯并噻唑铜配合物与ct-DNA的相互作用。结果表明该化合物以插入式与ct-DNA键合。Schiff base condensed from 2-hydroxy-l-naphthalde-hyde with 2-amino-benzothiazole and its copper complexes were synthesized, and its structure has been characterized by IR, UV, TG-DTA, elements analysis and molar conductance analysis. The interaction between its complexes and ct-DNA has been studied by electronic absorption spectroscopy, fluorescence spectroscopy, viscosity measurement in buffer solution of Tris-HCl（pH 7.22）. All of the results indicated that the interaction of the complexes with ct-DNA was intercalation.

关 键 词：希夫碱 铜配合物 小牛胸腺脱氧核糖核酸 

分 类 号：O657.61[理学—分析化学]