肺腺癌内皮抑素表达与微淋巴管密度及淋巴转移的关系  

Expression of endostatin and impact on microlymphatic vessel density in lung adenocarcinoma

作　　者：肖天辉[1] 董晓鹏[1] 刘延红[1] 赵晓光[1] 

机构地区：[1]山东大学第二医院,济南250033

出　　处：《山东医药》2010年第45期21-23,共3页Shandong Medical Journal

基　　金：山东省自然科学基金青年基金资助项目(Q2007C12)

摘　　要：目的研究内皮抑素在肺腺癌中的表达及其与淋巴管生成和淋巴转移的关系。方法免疫组化法检测60例肺腺癌内皮抑素蛋白的表达及肺腺癌组织微淋巴管密度(MLVD),分析内皮抑素表达与MLVD及淋巴结转移的关系。结果肺腺癌组织内皮抑素蛋白阳性率[61.7%(37/60)]高于癌旁正常组织[23.3%(14/60)](P<0.01);其表达与肿瘤分期、淋巴结转移有关。内皮抑素阳性组MLVD(7.68±1.89)低于阴性组(9.17±1.95)(P<0.01),随内皮抑素表达程度加强,MLVD值减小。结论内皮抑素在抑制肺腺癌淋巴管生成及淋巴转移中可能起一定作用。Objective To investigate the expression of endostatin and impact on microlymphatic vessel density in lung adenocarcinoma.Methods The expression of endostatin and microlymphatic vessel density（MLVD） were assayed by means of immunohistochemistry in 60 cases with lung adenocarcinoma.Results The positive expression rate of endostatin in tumor tissue [61.7%（37/60）]was higher than that of corresponding adjacent non-neoplastic tissue[23.3%（14/60）]（P0.01）.MLVD was significantly lower in endostatin positive expression group（7.68±1.89）than that in negative expression group（9.17±1.95）（P0.01）,and MLVD decreased with the increase of the endostatin expression level.In addition,there was a close relationship between the expression level of endostatin and the stage of TNM.Conclusion Endostatin may contribute to the restraint of lymphangeogenisis and lymph node metastasis in lung adenocarcinoma.

关 键 词：肺肿瘤 内皮抑素 淋巴管扩张 

分 类 号：R734.2[医药卫生—肿瘤]