子宫肌瘤与雌激素受体α基因多态性关系的临床研究  

Estrogen receptor α gene polymorphisms in women with leiomyoma

作　　者：王佳茵[1] 张海珍[1] 关云谦[1] 周齐[1] 

机构地区：[1]首都医科大学宣武医院细胞治疗室,北京100053

出　　处：《北京医学》2010年第11期880-882,共3页Beijing Medical Journal

摘　　要：目的研究在中国汉族人群中,子宫肌瘤的发生与雌激素受体α(ERα)基因多态性之间的关系。方法采用聚合酶链反应限制性片段长度多态性(PCR-RFLP)来扩增ERα基因序列,用限制性内切酶对193名健康女性和92名子宫肌瘤患者的ERα基因扩增产物进行酶切,测定其基因多态性。结果 ER基因XbaI基因型及PvuⅡ基因型在子宫肌瘤组与对照组之间的分布无显著性差异(P=0.862及0.918),XbaI基因型等位基因(x、X)及PvuⅡ基因型等位基因(p、P)的分布两组比较均无显著性差异(P=0.893及0.781)。结论在中国汉族人群中,ERα基因多态性与子宫肌瘤的发生并无相关性。Objective To investigate the possible association between estrogen receptor （ER） α gene polymorphisms and leiomyoma in a Chinese （Han） population. Methods The distribution of the ERα gene polymorphisms in 285 Chinese （Han） females were examined, in which 92 were patients and 193 were healthy controls. Genomic DNA was obtained from whole blood. The ERα gene polymorphism was assessed by polymerase chain reaction -restriction fragment-length polymorphism （PCR-RFLP）. Results No significant difference between the leiomyoma patients and the controls in the frequencies of the polymorphisms in ERα gene in Chinese Han population could be found. Conclusion The polymorphism in the ERα gene is not associated with the establishment of leiomyoma in Chinese Han population.

关 键 词：子宫肌瘤 基因多态性 雌激素受体Α 

分 类 号：R737.33[医药卫生—肿瘤]