脂蛋白相关磷脂酶A_2与缺血性脑卒中的关系  

Relationship of Lipoprotein-associated Phospholipase A_2 with Ischemic Cerebral Stroke

作　　者：张向晖[1] 安中平[1] 

机构地区：[1]天津市环湖医院神经内科,天津300060

出　　处：《医学综述》2010年第21期3227-3230,共4页Medical Recapitulate

摘　　要：脂蛋白相关磷脂酶A2(Lp-PLA2)是磷脂酶A2超家族中的一个亚型,不仅可以水解血小板活化因子,还能水解低密度脂蛋白氧化过程中形成的氧化磷脂生成溶血卵磷脂和氧化型游离脂肪酸。研究证实Lp-PLA2参与动脉粥样硬化的形成,与斑块的不稳定性密切相关。缺血性脑卒中患者Lp-PLA2活性明显升高,而且与神经功能缺损相关,提示Lp-PLA2不仅可能成为独立的缺血性脑卒中风险预测因子,还可以初步评估预后。Lp-PLA2抑制剂研制及基因治疗,为延缓动脉粥样硬化进展、稳定粥样斑块提供了可能。The lipoprotein-associated phospholipase A2 （ Lp-PLA2 ） ,a subtype of the phospholipase A2 superfamily,can hydrolyze platelet-activating factor and oxidize phospholipids from low-density lipoprotein as well,resulting in the production of lysophosphatidylcholine and oxidized fatty acids. Studies have demonstrated that Lp-PLA2 is an important factor in the process of atherosclerosis and associated with the instability of atherosclerotic plaques. Plasma Lp-PLA2 activity increases significantly in patients with ischemic stroke,associated with neurological deficiency. Lp-PLA2 may become an independent risk factor for predicting ischemic stroke and evaluating the prognosis. Lp-PLA2 inhibitor and gene therapy may inhibit the formation of atherosclerotic plaques and enhance the stability of plaques.

关 键 词：脂蛋白相关磷脂酶A2 动脉粥样硬化 缺血性脑卒中 

分 类 号：R743.3[医药卫生—神经病学与精神病学]