超重、肥胖与肝癌关系的Meta分析  

Overweight, Obesity and Risk of Liver Cancer： A Meta - analysis of Cohort Studies

作　　者：陈瑶[1] 叶方立[1] 万远太[2] 

机构地区：[1]武汉科技大学医学院预防教研室,湖北武汉430064 [2]武汉科技大学附属天佑医院消化内科,湖北武汉

出　　处：《医学新知》2010年第5期443-445,448,共4页New Medicine

摘　　要：目的 评价超重和肥胖是否会增加患肝癌的危险性.方法 通过检索MEDLINE、EMBASE和中国期刊全文数据库等,获得1966～2007发表的有关体重超标和肝癌危险性关系的队列研究资料,进行Meta分析.选择一般反向方差,采用随机效应模型,计算合并RR值及相应的95%CI.结果 共检索到符合要求的文献11篇,其中关于超重的7篇（共计5 037例）、肥胖的10篇（共计6 042例）.与正常体重者相比,超重者患肝癌的合并相对危险度（RR合）为1.16（95%CI：1.02～1.32）,肥胖者患肝癌的RR合为1.89（95%CI：1.51～2.35）.结论 肥胖与超重会增加肝癌发生的危险性.Objective To assess whether overweight and obesity may increase the risk of liver cancer. Methods Cohort studies of excess body weight and risk of liver cancer were identified for a meta - analysis by searching MEDLINE, EMBASE and China Full Text Journal databases from 1966 to June 2007. Results from individual studies were combined using a random - effect model and generic inverse variance. Results We identified 11 cohort studies, of which 7 on overweight （with a total of 5037 cases） and 10 on obesity （with 6042 cases） were suitable for meta - analysis. Compared with persons of normal weight, the combined relative risk of liver cancer patients were 1. 16 （95 % confidence interval （CI） ： 1.02 - 1.32） for those who were overweight and 1.89 （95 % CI ： 1.51 - 2.35 ） for those who were obese. Conclusion This meta - analysis finds that excess body weight is associated with an increased risk of liver cancer.

关 键 词：身体质量指数 队列研究 肝癌 META分析 一般反向方差 

分 类 号：R735.7[医药卫生—肿瘤]