多肽型阳离子脂质体的研究进展  

The Development of Polypeptide Cationic Liposome

作　　者：赵轶男[1] 张树彪[1] 崔韶晖[1] 王胜男[1] 孙杨[1] 

机构地区：[1]大连民族学院生命科学学院,辽宁大连116600

出　　处：《化学世界》2010年第11期701-704,669,共5页Chemical World

基　　金：国家自然科学基金(20876027);教育部新世纪优秀人才支持计划(NCET-08-0654)

摘　　要：多肽型阳离子脂质体作为一种重要的非病毒基因载体,克服了其他阳离子脂质体转染效率低、具有一定细胞毒性的缺点,在基因转运方面具有广阔的应用前景。在近年来多肽型阳离子脂质体研究的基础上,论述了多肽型阳离子脂质体在类脂的结构设计、脂质体制备及其在基因转运方面应用的研究现状,展望了多肽型阳离子脂质体的发展方向。As an important non-viral gene vector,polypeptide cationic liposome has overcome some disadvantages of other cationic liposomes,such as low transfection efficiency and cell toxicity,and shown a potential application in disease treatment and gene transfer.Based on the studies of recent years,summarizes the latest development of polypeptide cationic liposome for gene delivery,including the structure design of polypeptide lipid,liposomal preparation and the application in the field of gene transfer,and it also gives some suggestions on the development trend of polypeptide cationic liposome for gene delivery.

关 键 词：多肽 阳离子脂质体 非病毒载体 基因转运 

分 类 号：R941[医药卫生—药剂学]