HPV基因分型检测与非典型鳞状细胞的相关性研究  

The Relationship between HPV Subtypes and Atypical Squamous Cells of Undetermined Significance

作　　者：王旭洲[1] 余英豪[1] 黄惠娟[1] 宋屿娜[1] 谢飞来[1] 吴敏[1] 

机构地区：[1]南京军区福州总医院,350025

出　　处：《实用癌症杂志》2010年第6期554-556,共3页The Practical Journal of Cancer

基　　金：卫生部科研基金资助项目(WKJ2007-3-001)

摘　　要：目的探讨人乳头瘤病毒(HPV)分型检测与难以确定的非典型鳞状上皮细胞(Asc-us)分流监测的相关性及其临床意义。方法对50例薄层液基细胞学(LCT)检查结果为Asc-us的病例,进行HPV基因扩增分型检测,所有病例均同时进行组织病理学检查。结果 50例Asc-us病例中HPV阳性23例,其中高危型17例。以组织病理学CINⅡ～CINⅢ级作为子宫颈高度病变判断标准,子宫颈高度病变在高危型HPV阳性组、低危型阳性组和全阴性组发生率分别为88.2%,66.6%和59.3%,差异有统计学意义(P<0.05)。结论 HPV基因分型检测可靠准确,对LCT结果为Asc-us的病例进行快速筛查,能够有效进行分流监测,对降低子宫颈高度病变的漏诊率具有重要意义。Objective To explore the relationship between HPV subtypes and atypical squamous cells of undetermined significance（ASC-US） and its clinical significance.Methods 50 cases of ASC-US diagnosed with thin-layer liquid-based cytology test（LCT） were detected with gene amplification and HPV genotyping,and all patients were also diagnosed by histopathological examination.Results Among 50 cases with ASC-US,23 were positive for HPV,and 17 cases were positive for high risk group.Taken CINⅡ-CINⅢ as the criterion of high-level cervical lesions,the incidence rate of high-level cervical lesions in high risk HPV positive group,low-risk positive group,negative group were 88.2%,66.6% and 59.3%,and the difference was statistically significantit（P 0.05）.Conclusion As a reliable and accurate tool,HPV genotyping test can rapid screen Asc-us found with LCT.Also it can be used as a effective triage monitoring approach,and it is of great value for reducing the rate of missed diagnosis of severe cervical lesions.

关 键 词：人乳头瘤病毒 非典型鳞状上皮细胞 子宫颈上皮内瘤变 

分 类 号：R737.33[医药卫生—肿瘤]