多指标正交设计优选丹参水提液醇沉工艺  

Optimization of Alcohol Precipitation Process of Salviae miltiorrhizae Water-extraction Solution by Orthogonal Design with Multi-index Comprehensive Evaluation

作　　者：袁佳[1] 李页瑞[1] 陈勇[1] 王龙虎[1] 刘雪松[1] 

机构地区：[1]浙江大学药学院,浙江杭州310058

出　　处：《中国医药工业杂志》2010年第11期826-829,共4页Chinese Journal of Pharmaceuticals

基　　金：浙江省自然科学基金(Y2080704)

摘　　要：采用正交设计法和多指标综合评分法,以除杂量和总酚酸保留率为指标,优化丹参水提液醇沉工艺中初始药液密度、加入乙醇的浓度、搅拌速度和乙醇加入速度4个工艺参数。最佳工艺为:450 r/min搅拌下,将90%乙醇以60.9 ml/min的速度加至初始密度为1.20 g/ml的丹参水提液中,至溶液中乙醇终浓度为80%。3批样品醇沉后的除杂量为6.03 g,总酚酸保留率为67.2%。An orthogonal design with multi-index comprehensive evaluation was adopted to optimize the alcohol precipitation process of Salviae miltiorrhizae water-extraction solution with impurity removal and retention rate of total salvianolic acids as indexes.The optimized process was to add 90% ethanol to 1.20 g/ml of Salviae miltiorrhizae water-extraction solution at a constant rate of 60.9 ml/min and stirring speed of 450 r/min until the final ethanol concentration of 80%.The impurity removal and retention rate of total salvianolic acids were 6.03 g and 67.2%.

关 键 词：丹参 醇沉工艺 正交设计 多指标综合评分法 

分 类 号：R284[医药卫生—中药学]