直肠癌及癌周不同部位粘膜表皮生长因子受体表达的研究  

STUDY OF EXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTORINMUCOSAOF RECTAL CANCER AND THE MUCOSA OF THE PERIPHERAL AREAS

作　　者：徐德龙[1] 王克诚[1] 刘宁青[1] 肖文华[1] 

机构地区：[1]河北医科大学第三医院外科,河北省石家庄市050051

出　　处：《中国煤炭工业医学杂志》1999年第3期273-274,共2页Chinese Journal of Coal Industry Medicine

基　　金：河北省卫生厅科研基金

摘　　要：目的探讨人体直肠癌周不同部位粘膜表皮生长因子受体（ＥＧＦＲ）在正常直肠粘膜、直肠腺瘤、直肠癌及癌周不同部位粘膜上皮细胞中的表达及意义。方法采取正常直肠粘膜１０例，直肠腺瘤２０例，直肠癌远旁、近旁和癌粘膜各３０例。应用免疫组化染色（ＳＰ法）检测ＥＧＦＲ的表达。结果正常直肠粘膜、直肠腺癌和直肠癌粘膜ＥＧＦＲ阳性率分别为０、３０％和７３．３％，各组间比较均有显著性差异（Ｐ＜０．０５）。直肠癌远旁、近旁和癌粘膜ＥＧＦＲ阳性率分别为３．３％、２０．０％和７３．３％，三者之间均有显著性差异（Ｐ＜０．０５）。结论ＥＧＦＲ表达与直肠癌的分化程度、分期和淋巴结转移有关；与组织学类型无关；ＥＧＦＲ与直肠癌的发生发展密切相关。Objective To study the expression and the significanceof epidermal growth factor receptor (EGFR ) in mucosa of rectal adenomaand rectal cancer as well as in the mucosa of the peripheral areas of the cancer. Method S-P (Streptavidin/Peroxidasa) immunohistochemicalmethod was used to detect the expression of EGFR in 30 cases of rectal carcinoma, 20 cases of rectal adenoma and 10 cases witth normal rectalmucosa. Result The positive rates of EGFR in normal rectal mucosa, rectal adenoma and rectal carcinoma were 0. 0 %, 30% and 73. 33 %respectively and the difference was significant (P < 0. 05 ). The positiverates of EGFR in cancer--ckstant mucodsa (CDM ), cancer--adjacent mucosa (CAM ) and cancer mucosa were 3. 33 %. 20% and 73. 33 N respectively alsowith significant difference (P< 0. 05). Conclusion In rectal cancer theexpression of EGFR is correlated with the degree of itsdifferentiation, stage and lymphatic metastases, but has nothing to dowith the histological types of rectal cancer. EGFR is closelycorrelated with the genesis and development of rectal cancer.

关 键 词：表皮生长因子 受体 腺癌 直肠癌 癌周组织 

分 类 号：R735.370.2[医药卫生—肿瘤]