MDA-7/IL-24——肿瘤基因治疗的新武器  

MDA-7/IL-24——A potential new weapon for tumor gene therapy

作　　者：郑鹏生[1,2] 顾婷婷[1] 

机构地区：[1]西安交通大学医学院第一附属医院妇产科学系生殖医学科,陕西西安710061 [2]西安交通大学医学院环境与疾病相关基因教育部重点实验室,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2010年第6期651-658,663,共9页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：国家自然科学基金资助项目(No.30571951);国家自然科学杰出青年基金项目(No.30725043);西安交通大学985-2期工程~~

摘　　要：通过消减杂交法从人黑色素瘤细胞中分离出来的黑色素瘤分化相关基因(melonoma differentiation associatedgene 7,MDA-7),因其分子生物学特性与IL-10相似,故将其归入IL-10家族,并重新命名为IL-24。位于人染色体1q32的MDA-7/IL-24基因在原始黑色素瘤细胞及人免疫相关组织中表达。MDA-7/IL-24的膜受体IL-20R1、IL-20R2和IL-22R1在不同组织、细胞中的分布存在差异。MDA-7/IL-24具有广泛的抗肿瘤生物学作用。它能够通过膜受体或非受体介导的凋亡途径对多种肿瘤细胞产生杀伤作用,而不影响正常细胞。此外,MDA-7/IL-24还具有抑制肿瘤新生血管形成、增强放疗敏感性和免疫调节作用。作为一种具有多种抗肿瘤功能的细胞因子,MDA-7/IL-24在临床Ⅰ期试验中已显示出良好的治疗效果,将成为肿瘤基因治疗的新武器。MDA-7/IL-24 is isolated from the IFN-β and mezerein treated human melanoma cell line by differentiation induction subtraction hybridization.MDA-7/IL-24 is classified as a member of the IL-10 gene family because of the similarities in molecular biological characteristics.MDA-7/IL-24 gene is located at the 1q32 and expresseds in primary melanomas and normal human＇s immune-related tissues.The membrane receptors of MDA-7/IL-24,IL-20R1/IL-20R2 and IL-22R1/IL-20R2 are distributed disparitively in different cells and tissues.MDA-7/IL-24 has been found to display ubiquitous anti-tumor biological properties： inducing tumor cell apoptosis,inhibiting angiogenesis and enhancing the sensitivity of radiotherapy,but having no damage to the normal cells.As a multifunctional anti-tumor cytokine,MDA-7/IL-24 has been confirmed of the anti-tumor effect in the phaseⅠclinical trial,and it becomes a potential new weapon for tumor gene therapy.

关 键 词：MDA-7/IL-24 肿瘤 凋亡 

分 类 号：R730.5[医药卫生—肿瘤]