PTEN蛋白表达与子宫内膜癌的相关性研究  

Expression and significance of PTEN protein in endometrial carcinoma

作　　者：杨琳琳[1] 黄云超[1] 卢玉波[1] 杨宏英[1] 杨谢兰[1] 

机构地区：[1]云南省肿瘤医院,云南南宁650031

出　　处：《现代肿瘤医学》2010年第11期2243-2245,共3页Journal of Modern Oncology

摘　　要：目的:探讨子宫内膜癌中抑癌基因PTEN的表达,及其与子宫内膜癌临床病理特征及预后的关系。方法:采用免疫组化检测16例正常子宫内膜、32例子宫内膜癌组织中PTEN蛋白的表达,分析其与临床病理的相关性。结果:抑癌基因PTEN在子宫内膜癌组中蛋白阳性表达显著低于正常子宫内膜组(P<0.01)。PTEN阳性表达的缺失与组织学分级与肌层浸润深度有关(P<0.05)。结论:PTEN基因突变及蛋白表达缺失与子宫内膜癌的发生有关,与子宫内膜癌的分化程度、肌层浸润深度有相关性。Objective：To study the significance and expression of tumor suppressor gene PTEN in adenocarcinoma endometrium.Methods： The expression of tumor suppressor gene PTEN was examined in nomal endometrium（16 cases） and endometrioid adenocarcinoma（32cases） using immunohistochemical technique.Results： The expression of PTEN protein in endometrioid adenocarcinoma group was significantly lower than that of normal endometrium group（P0.01）.PTEN protein expression was significantly associated with histological grade and muscular invasion（P0.05）.Conclusion： PTEN gene mutation or expression loss of PTEN is related with endometrial carcinoma.Expression loss of PTEN is usually found in low histological grade,deep muscular invasion endometrial carcinoma.

关 键 词：抑癌基因PTEN PTEN蛋白 子宫内膜癌 

分 类 号：R737.33[医药卫生—肿瘤]