HIF-1α和P53蛋白的表达对肾透明细胞癌预后的影响  

Effect of hypoxia inducible factor-1 alpha and P53 expression on prognosis of clear cell renal cell Carcinoma

作　　者：舒博[1] 申钧[1,2] 陈鹏[1] 王海江[1] 

机构地区：[1]新疆医科大学附属肿瘤医院泌尿外科,新疆乌鲁木齐830011 [2]岳阳市岳化医院泌尿外科,湖南岳阳410014

出　　处：《现代泌尿外科杂志》2010年第6期435-439,共5页Journal of Modern Urology

摘　　要：目的本研究旨在探讨缺氧诱导因子1α(HIF-1α)和P53蛋白在人肾透明细胞癌组织中的表达及其对患者预后的影响。方法应用免疫组化方法检测65例肾透明细胞癌组织中HIF-1α和P53蛋白的表达情况,通过生存曲线法比较阳性组和阴性组患者的预后情况。结果 HIF-1α和P53蛋白表达的阳性率分别为40.0%(26/65)和52.3%(34/65);HIF-1α表达与肾透明细胞癌的组织学分级、临床分期和淋巴结转移有关(P<0.05);HIF-1α蛋白阳性组患者的生存期明显较阴性组短(P=0.004);P53蛋白表达与肾透明细胞癌患者性别、年龄、肿瘤大小、组织学分级、临床分期、淋巴结转移及生存期均无关(P>0.05);HIF-1α蛋白P53蛋白的表达之间存在相关性(r=0.402,P=0.001)。结论 HIF-1α的表达与肾透明细胞癌患者的预后相关,其阳性表达提示患者预后不良;检测HIF-1α表达水平有助于肾细胞癌预后评估。Objective This study was designed to investigate the expression of HIF-1α and P53,and their effect on prognosis of clear cell renal cell carcinoma（ccRCC）.Methods SP immunohistochemistry was used to determine the expression of HIF-1α and P53 in patients with ccRCC.Kaplan-Meier and Log-rank test were used to compare the survival time of positive staining group and negative staining group.Results The positive rate of HIF-1α and P53 was 40.0% and 52.3%,respectively.The positive expression of HIF-1α was related to the clinical stage,histological grade and lymph node metastasis of ccRCC（P0.05）.The survival time in positive HIF-1α group was significantly shorter than that in negative HIF-1α group（P=0.004）.The positive expression of P53 was not related to the age,sex,tumor size,clinical stage,histological grade,lymph node metastasis and survival time（P0.05）.There was significant correlation between HIF-1α and P53 in ccRCC（r=0.402,P=0.001）.Conclusion The expression of HIF-1α was closely correlated with the prognosis of ccRCC,and the positive expression of HIF-1α suggested poor prognosis in patients with ccRCC.Examination of HIF-1α expression may be useful for predicting prognosis.

关 键 词：肾肿瘤 缺氧诱导因子-1Α P53 预后 免疫组织化学 

分 类 号：R737.11[医药卫生—肿瘤]