sICAM-1与视网膜分支静脉阻塞性黄斑水肿的关系  

Relationship between Aqueous Soluble Intercellular Adhesion Molecule-1 and Macular Edema Associated with Branch Retinal Vein Occlusion

作　　者：石霞群 袁媛[2] 管怀进[2] 

机构地区：[1]南通市崇川区钟秀街道社区卫生服务中心 [2]南通大学附属医院,江苏南通226000

出　　处：《泰州职业技术学院学报》2010年第5期19-20,共2页Journal of Taizhou Polytechnic College

摘　　要：目的研究可溶性细胞粘附分子-1(sICAM-1)与视网膜分支静脉阻塞性黄斑水肿的关系。方法取19例BRVO性黄斑水肿患者的房水样本,采用酶联免疫吸附试验测定sICAM-1的浓度。结果与正常对照(中位数:3.3ng/mL)相比,BRVO中房水sICAM-1浓度(中位数:6.8ng/mL)明显升高(P=0.005),且与黄斑水肿的严重程度相关(P=0.02)。结论sICAM-1与BRVO中形成黄斑水肿相关。测定房水中sICAM-1的浓度有助于评估黄斑水肿的严重程度。Objective This study investigated whether soluble intercellular adhesion molecule-1（sICAM-1） has a role in the pathogenesis of macular edema associated with branch retinal vein occlusion（BRVO）.Methods A retrospective case control study was performed in 19 patients with BRVO and macular edema.Aqueous humor samples were obtained during the performance of cataract surgery.sICAM-1 levels in aqueous humor were determined by enzyme-linked immunosorbent assay.Results Aqueous humor levels of sICAM-1（median：6.8ng/mL） were significantly elevated in BRVO patients compared with the control group （median：3.3ng/mL）（P = 0.005）.Furthermore,aqueous levels of sICAM-1 were correlated with the severity of macular edema（P = 0.020）.Conclusion sICAM-1 may be involved in the pathogenesis of macular edema associated with BRVO.Measurement of aqueous humor sICAM-1 levels may be useful for assessment of BRVO patients with macular edema.

关 键 词：可溶性细胞粘附分子-1 视网膜分支静脉阻塞 黄斑水肿 

分 类 号：R774[医药卫生—眼科]