三阴性乳腺浸润性导管癌的临床病理特征探讨  

Pathological features of triple-negative invasive ductal carcinoma of breast

作　　者：王明华[1] 郑晶[1] 丁莉丽[1] 罗志飞[1] 王林海[1] 吴媛媛[1] 

机构地区：[1]海南医学院病理学教研室,海南海口571101

出　　处：《海南医学院学报》2010年第11期1409-1411,1415,共4页Journal of Hainan Medical University

基　　金：海南医学院科研基金资助学报项目(0020100387)~~

摘　　要：目的:总结ER、PR、人表皮生长因子受体-2(HER-2)表达阴性(三阴性)乳腺浸润性导管癌患者的临床资料,了解其临床病理特征。方法:回顾性分析三阴性乳腺癌组(TNBC)和非三阴性乳腺癌组(non-TNBC)的组织学分级及淋巴结转移情况,了解三阴性乳腺浸润性导管癌的组织学分级和淋巴结转移特点。结果:TNBC组患者的中位年龄为39岁,有乳腺癌家族史者8例,占34.8%,组织学分级分别为Ⅰ级3例,Ⅱ级9例,Ⅲ级11例,淋巴结阳性转移率为19.5%,non-TNBC组患者发病平均年龄为48岁,有乳腺癌家族史者36例,占19.6%,组织学分级分别为Ⅰ级68例,Ⅱ级80例,Ⅲ级36例,淋巴结阳性转移率为22.4%。与non-TNBC组相比,TNBC组患者的中位年龄、组织学分级和淋巴结阳性转移率均明显不同,二者之间的差异有显著性意义,但就本组资料统计结果而言,尚不能认为乳腺癌家族史对TNBC的发生起重要作用,且TNBC组的淋巴结转移率低于non-TNBC组。结论:三阴性乳腺浸润性导管癌是一种高危乳腺癌,多发于较年轻的患者,其组织学分级多为高级别。Objective： To summarize the pathological features of triple-negative invasive ductal car cinoma of breast. Methods： Histological grade and lymph node metastasis of triple negative breast cancer （TNBC, A group） and non triple negative breast cancer patients （non TNBC, B group） were retrospec tively analyzed. Results The median age of patients of TNBC was 39 years old, and 8 cases （34. 8%, 8/23） had family history of breast cancer. Three cases in TNBC group were at grade Ⅰ , 9 cases at grade Ⅱ and 11 cases at grade Ⅲ, respectively; and the ratio of lymph node metastasis was 19.5%. The median age of patients of non-TNBC was 48 years, and 36 cases （19.6%,36//184） had family history. 68 cases in non-TNBC were at grade Ⅰ , 80 cases at grade Ⅱand 36 cases at grade Ⅲ and the ratio of lymph node metastasis was 22.4%. There were significant differences in median age, histological grade and lymph node metastasis in two groups. Conclusions： Triple negative invasive ductal carcinoma of breast is highly risk, and occurs mainly in younger patients, with more higher histological grade level.

关 键 词：乳腺浸润性导管癌 三阴性乳腺癌 组织学分级 

分 类 号：R737.9[医药卫生—肿瘤]