前列腺特异抗原在42例前列腺癌诊治中的应用  

Application of PSA to diagnosis and treatment in 42 cases of prostatic carcinoma

作　　者：高江原[1] 郑祥奇[2] 杨林[2] 

机构地区：[1]重庆医药高等专科学校,400031 [2]重庆市急救医疗中心泌尿外科,400014

出　　处：《重庆医学》2010年第22期3061-3062,共2页Chongqing medicine

摘　　要：目的探讨血清总前列腺特异抗原(TPSA)、游离前列腺特异抗原(FPSA)和FPSA/TPSA比值(F/T比值)在前列腺癌诊治中的应用价值。方法使用Liaisin全自动化学发光免疫分析仪检测经临床确诊的42例前列腺癌(PCa)和84例良性前列腺增生(BPH)患者和62例健康者血清TPSA、FPSA含量,并计算F/T。结果 PCa组患者TPSA、FPSA水平均明显升高。BPH与PCa两组患者间在诊断灰区内差异无统计学意义(P>0.05),而F/P比值差异有统计学意义(P<0.01)。结论在前列腺癌诊治中,T/P比值的诊断价值,明显优于单纯使用TPSA。Ojective To research the clinical application of serum prostate specific antigen（PSA）,free-prostate specific antigen（f-PSA）and（f-PSA）/（PSA）ratio for the diferential diagnosis of prostatic carcinoma（PCa）.Methods Serum samples were obtained from 62 normal men,42 patients with prostatic carcinoma（PCa）and 84 patients with untreaded benign prostate hyperplasia（BPH）.The levels of PSA and f-PSA in serum were determined by auto-immunochemieal luminescence method,and the ratio of f-PSA/ PSA was calculated.Results The various indexes of the PCa group were signifieamly higher than those of the control group.The difference of PSA had no statistical significonce between the PCa and BPH groups（P〉0.05）.The FPSA/PSA ratio had statistical difference between PCa group and BPH group（P〈0.01）.Conclusion The ratio of PSA/PSA is superior to simple PSA in the diagnosis of prostatic carcinoma（PCa）.

关 键 词：前列腺特异抗原 前列腺癌 前列腺增生 

分 类 号：R737.25[医药卫生—肿瘤] R730.45[医药卫生—临床医学]