Ⅲ期非小细胞肺癌FDG PET-CT体积与预后关系分析  

The correlation between FDG PET - CT metabolic tumor volume and prognosis in lung cancer

作　　者：张华琦[1] 于金明[2] 李明焕[1] 冯瑞[2] 周伟[1] 杨国仁[3] 

机构地区：[1]山东省肿瘤医院特需科,济南250117 [2]山东省肿瘤医院放疗二科,济南250117 [3]山东省肿瘤医院PET-CT中心,济南250117

出　　处：《中华放射肿瘤学杂志》2010年第6期504-507,共4页Chinese Journal of Radiation Oncology

基　　金：国家自然科学基金（30700196）

摘　　要：目的 探讨Ⅲ期非小细胞肺癌（NSCLC）氟标记脱氧葡萄（FDG）PET-CT原发灶代谢肿瘤体积（MTV）与预后相关性,通过MTV和最大标准摄取值（SUVmax）对预后影响的对比分析寻找预测预后的最佳指标.方法 搜集本院2004-2007年行FDG PET-CT全身扫描的56例Ⅲ期NSCLC患者,治疗前行PET-CT检查,治疗均采取同步放化疗,随访至治疗结束后2年.计算MTV与SUVmax值,进一步分析总生存与MTV和SUVmax的关系.结果 56例患者平均总生存时间为14.5个月,KaplanMeier法分析显示MTV对总生存影响有统计学意义（x2=5.42,P=0.014）;SUVmax与总生存无关（x2=0.74,P=0.391）.Cox回归模型分析显示MTV、SUVmax与总生存相关（x2=5.54,P=0.019;x2=4.47,P=0.031）.结论 Ⅲ期NSCLC患者的FDG PET-CT MTV与总生存密切相关,有可能作为预测因子用于评价和预测预后.Objective To assess the prognostic value of tumor burden measured by 18F-fluorodeoxy glucose-positron emission tomography （ FDG PET） imaging for stage Ⅲ NSCLC）. Methods Fifty-six patients with lung cancer were analyzed, to whom staging PET-CT scans before treatment concurrent chemoradiotherapy and 2-year follow-up were performed. , Relationship between overall survival （OS） and metabolic tumor volume （MTV） and maximum standardized uptake value （SUVmax） were determined.Results The estimated median OS for the cohort were 14. 5 months. Kaplan-Meier analysis showed that MTV had a significant effect on OS （x2 =5.42 ,P =0. 014）. No significant relationship was found between SUVmax and OS （ x2 = 0. 74, P = 0. 391 ）. According to multivariate Cox regression analysis, MTV and SUVmax wereassociatedwithincreaseddeath （ x2 = 5.54, P = 0.019; x2 = 4.47, P = 0.031 ）. Conclusions This study shows that higher tumor burden assessed by PET MTV is an independent unfavorable prognostic factor in lung cancer, MTV is valuable for predicting overall survival and could be a prognostic factor.

关 键 词：癌 非小细胞肺/放射性核素显像 氟标记脱氧葡萄糖 体层摄影术 正电子发射型 预后 

分 类 号：R734.2[医药卫生—肿瘤]