结直肠癌Lgr5表达对患者预后的影响  

Higher expression of Lgr5 predicts poor prognosis in human colorectal cancer

作　　者：彭亮[1] 梁纯[2] 梁燕[1] 胡晶晶[1] 王菁[1] 姜泊[1] 王新颖[1] 

机构地区：[1]南方医科大学南方医院消化科,510515 [2]香港科技大学生命科学部生物化学分部

出　　处：《现代消化及介入诊疗》2010年第5期284-287,共4页Modern Interventional Diagnosis and Treatment in Gastroenterology

摘　　要：目的探讨Lgr5在人结直肠癌中的表达与临床病理特征之间的联系以及对患者预后的影响。方法采用免疫组织化学SP方法检测169例结直肠癌患者术后组织石蜡切片标本,分析Lgr5表达与临床病理特征之间的联系,并采用Kaplan-Meier法分析Lgr5表达与患者生存预后的关系。结果 Lgr5在正常大肠黏膜组织中弱表达或者阴性表达,而在结肠癌组织中高表达,并且表达与Duke C+D期、肿瘤远处结转移以及分化程度有关(P<0.05;P<0.001;P=0.024);与年龄、性别、肿瘤发生部位以及淋巴结转移无关。Lgr5高表达的患者术后100个月生存率明显低于低表达或者阴性表达的患者。结论 Lgr5在结直肠癌组织中高表达可以作为判定结直肠患者预后较差的一个新的指标。Objective To analyse the relationship between Lgr5 expression and clinicopathological features,and to evaluate prognostic value of Lgr5 for patients with colorectal cancer. Methods One hundred and sixty-nine primary colorectal cancer tissues were examined with immunocytochemistry. The associations between Lgr5 expression and the clinicopathological features as well as survival of patients were analyzed with the Kaplan-Meier statistical method. Results Among primary colorectal cancers,60% （102/169） were Lgr5 （＋ ve）,compared with 7% （2/30） in adjacent tissues. Furthermore,Lgr5 expression significantly associated with Duke＇s C＋D,low grade tumor,and distant metastasis （P 0.05; P 0.001; P = 0.024）,as well as poor prognosis （P = 0.001） in patients with colorectal cancer,but not associated with patient＇s gender,age,tumor position,or lymph nodal metastasis. Conclusion Our data suggest that Lgr5 expression may be a novel prognostic marker for colorectal cancer patients.

关 键 词：结直肠癌 免疫组织化学 LGR5 预后 

分 类 号：R735.37[医药卫生—肿瘤]