神经营养因子影响肠道的研究进展  

Advances in understanding the role of neurotrophins in physiological and pathological processes in the intestinal tract

作　　者：徐国萍[1] 范一宏[1] 吕宾[1] 

机构地区：[1]浙江中医药大学第一附属医院消化内科,浙江省杭州市310006

出　　处：《世界华人消化杂志》2010年第27期2884-2888,共5页World Chinese Journal of Digestology

摘　　要：神经营养因子家族在神经细胞的生长发育、保护修复过程中起着极其重要的作用.胶质源性神经营养因子是最具有促进神经元生长、分化和修复潜力的营养因子,他可影响肠道神经元的发育和神经递质的表达;脑源性神经营养因子在肠内神经系统发育有着重要的作用,他参与肠道感染和胃肠动力调节;神经营养因子-3可增加肠肌层神经结神经元所表达的兴奋性神经肽而加速结肠转运;睫状神经营养因子与其他神经营养因子对神经细胞有协同作用.本文综述了近年来关于神经营养因子影响肠道的研究进展.Neurotrophins（NT） play an important role in the process of neuronal growth,development,protection and repair.In recent years,great advances have been achieved in the research of neurotrophins.Glial cell line-derived neurotrophic factor is a nutritional factor that has the most potential to promote neuronal growth,differentiation and repair.It can also modulate intestinal neuronal growth and neurotransmitter expression.Brainderived neurotrophic factor plays an important role in the development of the enteric nervous system,intestinal infection,and the modulation of gastrointestinal motility.Neurotrophin-3 can increase excitatory peptides that are expressed by neurons in the intestinal muscularis to accelerate colonic transit.Ciliary neurotrophic factor and other neurotrophins have a synergistic effect on neurons.In this article,we will review the recent advances in understanding the role of neurotrophins in physiological and pathological processes in the intestinal tract.

关 键 词：神经营养因子 肠道 研究进展 

分 类 号：R574[医药卫生—消化系统]