长春地辛、异环磷酰胺和顺铂联合治疗晚期肺癌20例近期疗效观察  

Clinical Study of IVP Rigimen in Trentment of Lung Cancer

作　　者：谢正强[1] 李勇[1] 王作范 张谦[1] 李平[1] 李宏章[1] 李洪波 

机构地区：[1]湖北十堰东风汽车公司中心医院肿瘤科

出　　处：《中国肿瘤临床与康复》1999年第3期83-83,82,共2页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的观察长春地辛、异环磷酰胺和顺铂联合治疗晚期肺癌患者疗效和毒性。方法符合化疗条件的２０例晚期肺癌患者，均完成２周期以上的化疗。方案组成：ＶＤＳ３ｍｇ／ｍ２静注第１、８天，ＩＦＯ２ｇ／日静滴，第１－５天，ｍｅｓｎａ４００ｍｇ静滴，每８小时１次，ＤＤＰ３０ｍｇ／ｍ２第２－４天或８０ｍｇ／ｍ２，第１天，２１－２８天为一周期，完成二周期后评价疗效。结果有效率７５％（１５／２０），完全缓解率１５％（３／２０），部分缓解率６０％（１２／２０），其中小细胞肺癌有效率８３．３％（５／６）非小细胞肺癌７１．４％（１０／１４）。常见毒副反应是白细胞减少Ⅲ度－Ⅳ度，占８５％，其次恶心、呕吐Ⅲ度占２５％。结论该方案对晚期肺癌是疗效较高方案，有条件者可作为一线方案应用。Objective To observe the activity and toxicity of VDS、IFO and DDP regimen in treatment of lung cancer.Methods 20 advanced patients with lung cancer were evaluated after recerving 2 cycles of chemotherapy in IVP regimen (VDS 3mg/m 2 ivd 1、8,IFO 2g/d ivd 1-5,Mesna 400mg iv q8h,DDP 30mg/m 2 d 2-4 or 80 mg/m 2 d1,repeated every 3-4 weeks).Results Total remission rate is 75% (15/20),the complete remission rate is 15%(3/20),the part remission rate is 60%(12/20),the remission rate of SCLC and NSCLC are 83.3% (5/6) and 71.4% (10/14),respectively.The most common side effects were leukocytopenia (Ⅲ-Ⅳ°,85%),nausea and vomiting (Ⅲ°25%).Conclusions IVP regimen is one of the most effective regimens for advanced lung cancer. This regimen may be used as a first selection for eligible patients.

关 键 词：肺癌 长春地辛 异环磷酰胺 顺铂 疗效 

分 类 号：R734.205[医药卫生—肿瘤] R730.53[医药卫生—临床医学]