MicroRNAs在骨骼肌分化、发育中的作用  

The Role of MicroRNAs in Skeletal Muscle Differentiation and Development

作　　者：马继政[1] 张爱军[1] 

机构地区：[1]解放军理工大学理学院军事系,南京211101

出　　处：《河北体育学院学报》2010年第6期70-73,共4页Journal of Hebei Sport University

摘　　要：MicroRNAs(miRNAs)是一类高度保守的、非编码的小分子RNA。miRNAs能在转录后水平调控基因表达,参与骨骼肌增殖、分化和再生。运动诱导骨骼肌生理性适应机制涉及多种信号转导途径,取决于训练量、强度、训练的频率和蛋白的半衰期。并且这些适应性的特征表现和运动方式有关。但这些生理性适应性变化和确切机制并不清楚,存在非常复杂的基因调控网路。骨骼肌特异性miRNAs的发现,为运动诱导骨骼肌生理性适应机制研究提供了新的思路,有利于认识运动性骨骼肌适应分子机制。MicroRNAs（miRNAs） are highly conserved,small non-coding RNAs.MiRNAs can powerfully regulate gene expression at the post transcriptional leve1 and participate in skeletal muscle proliferation,differentiation,and regeneration.There are many signaling networks following exercise.These adaptations are determined by training volume,intensity,frequency and the half-life of the protein.Moreover,many features of the training adaptation are specific to the mode of exercise.However,the mechanisms involved in training adaptation remain unclear.Muscle specific miRNAs were found,which can provide a new method to understand the physiological adaptation to exercise and its molecular mechanism.

关 键 词：MICRORNAS 生理性适应 骨骼肌 

分 类 号：G804.2[文化科学—运动人体科学]