电化学法光仪测定血清与胸水癌胚抗原对良恶性胸腔积液的鉴别  

Measured CEA in plenral fluid and serum to differentiate benign or malignant pleural effusion

作　　者：石小平[1] 任君[1] 毛雁飞[1] 周兴珍[1] 

机构地区：[1]解放军第三二四医院检验科,重庆400020

出　　处：《国际检验医学杂志》2010年第11期1236-1237,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨胸腔积液患者血清及胸水癌胚抗原(carcirwembryonic amtigen,CEA)在鉴别良恶性胸腔积液中的作用。方法采用电化学发光免疫分析法分析96例胸腔积液患者入院第一次胸水与血清CEA水平及比值,其中恶性胸腔积液患者36例,良性胸腔积液患者60例。结果良性胸腔积液患者血清CEA90%,胸水CEA95%在正常参考范围(<3.4ng/mL);其他患者测定的略升高,但小于10ng/mL。良性胸腔积液患者的胸水CEA/血清CEA≤1。恶性胸腔积液患者血清CEA可正常或升高,胸水CEA升高且胸水CEA/血清CEA>1。结论同时检测患者胸水与血清CEA水平及其比值有助于临床胸水性质的诊断。Objective To discuss the function of differential diagnosis whether the pleural effusion is benign or malignant by measuring the CEA in serum and pleural fluid. Methods Serum and hydrothorax samples were collected from 96 patients with pleural effusion. Among them, 36 patients were suffered with malignant pleural effusion and 60 patients with benign pleural effusion,the concentration of CEA was determined by immunoradiometric assay. Results The CEA in serum and pleural fluid benign was in normal range with ratio of CEAp/CEAs less than 1. The CEA in serum was normal or higher in malignancy,CEA in pleural fluid was higher than in normal with ratio more than 1 of CEAp/CEAs. Conclusion Tumor maker CEA has high clinical value in the differential diagnosis of pleural effusion.

关 键 词：血清 胸水 癌胚抗原 诊断 鉴别 

分 类 号：R730.4[医药卫生—肿瘤]