热化疗对口腔颌面癌患者一氧化氮水平影响的研究  

Influence of Thermochemotherapy to the Nitric Oxide Level in Oral Cancer

作　　者：高向东[1] 杨海锋 王升志[1] 赵君[3] 毛祖彝[3] 

机构地区：[1]烟台毓璜顶医院口腔科,山东烟台264000 [2]烟台市口腔医院,山东烟台264000 [3]四川大学华西口腔医学院,成都610041

出　　处：《肿瘤预防与治疗》2010年第1期23-26,共4页Journal of Cancer Control And Treatment

基　　金：山东省自然科学基金(基金编号:Z2005C01);山东省优秀中青年科学家科研奖励基金(基金编号:2006BS03016)资助

摘　　要：目的:观察热化疗对口腔颌面癌患者NO水平的影响。方法:给予口腔颌面癌患者每周2次,5周一疗程的热化疗处理,处理后观察肿瘤的组织形态学变化,并采用硝酸还原酶法检测患者血清NO的浓度。结果:热化疗后,肿瘤生长受到明显抑制。热化疗前后NO含量有显著性差异(P<0.01)。结论:热化疗可以显著升高荷瘤宿主NO水平,高浓度时具有很好的抗肿瘤效应。Objective ： To observe the influence of thermoehemotherapy to the nitric oxide level of oral cancer. Methods： Patients with oral cancer were treated by thermochemotherapy twice a week. After treatment of 5 weeks, histomorphologies were observed, the levels of NO of tumor were detected through the nitrate reductase method. Results： After treatment, the growth of tumors was inhibited significantly. The levels of NO in oral cancer patients were significantly different before and after thermochemotherapy （P 〈 0. 01 ）. Conclusion： Thermochemotherapy can improve the levels of NO of tumor bearing significantly. High concentration of NO has an excellent anti-tumor effect.

关 键 词：一氧化氮 一氧化氮合成酶 肿瘤 热化疗 

分 类 号：R739.8[医药卫生—肿瘤]