广西肝癌高发区肝细胞癌危险因素的病例对照研究  

A Case Control Study on Risk Factors of Hepatocellular Carcinoma in Guangxi

作　　者：纪龙[1] 

机构地区：[1]泰山医学院公共卫生学院,山东泰安271000

出　　处：《肿瘤预防与治疗》2010年第6期453-457,共5页Journal of Cancer Control And Treatment

基　　金：国家自然科学基金资助项目(No.30660162);广西研究生教育创新计划资助项目(No.2008105981004M189)

摘　　要：目的:探讨广西肝癌高发区肝细胞癌的主要危险因素。方法:采用病例-对照研究的方法,对500例肝细胞癌患者和507例对照进行人口学资料、生活方式、社会经济因素、既往病史、家族史以及毒物接触史等调查;应用非条件Logistic回归模型进行单因素与多因素的分析。结果:单因素分析显示,吸烟(OR=4.63,95%CI:3.26-6.57)、饮酒(OR=5.86,95%CI:4.17-8.24)、食鱼生(OR=26.0,95%CI:8.12-83.24)和慢性HBV感染(OR=25.14,95%CI:17.86～35.38)为肝细胞癌的危险因素;多因素分析显示,肝细胞癌发病的独立危险因素为饮酒(OR=3.96,95%CI:2.49-6.30)、食鱼生(OR=8.87,95%CI:2.29-34.42)和慢性HBV感染(OR=9.86,95%CI:6.59-14.76)。结论:饮酒、食鱼生和慢性HBV感染,可能是广西肝癌高发区肝细胞癌的重要危险因素。Objective： To explore the risk factors of hepatocellular carcinoma in Guangxi. Methods： A case-control study included 500 HCC patients and 507 controls. All study subjects were surveyed by using a questionnaire to obtain demographic information, living environment, disease and family history, etc; Non-condition Logistic regression model univariate and multivariate analysis were used. Results： By univariate analysis, the following items could raise the risk of hepatocellular carcinoma morbility： smoking （OR = 4. 63, 95%CI： 3.26-6.57）, drinking（ OR = 5.86, 95%CI： 4. 17-8.24）, consumption of pieces of raw fish（OR = 26.0, 95% CI ： 8.12 - 83.24） and HBV infection （ OR = 25. 14, 95% CI ： 17.86 - 35.38） ; By multivariate analysis, drinking（ OR = 3. 96, 95% CI ： 2.49 - 6.30）, consumption of pieces of raw fish（ OR = 8.87, 95% CI ： 2. 29 - 34.42）, and HBV infection （ OR = 9. 86, 95%CI： 6. 59 - 14. 76） were the significant determinant factor for HCC. Conclusion： The risk factors on the development of HCC include drinking, consumption of pieces of raw fish and HBV infection.

关 键 词：肝细胞癌 危险因素 对照研究 LOGISTIC回归分析 

分 类 号：R735.7[医药卫生—肿瘤] R730.2[医药卫生—临床医学]