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机构地区:[1]四川省肿瘤医院病理科,成都610041 [2]四川大学华西医院,成都610041
出 处:《肿瘤预防与治疗》2010年第6期524-526,共3页Journal of Cancer Control And Treatment
摘 要:目的:探讨原发性皮肤间变性大细胞淋巴瘤(C-ALCL)的临床及组织病理学特征。方法:通过对1例复发C-ALCL患者的皮损行组织病理学及免疫组化检查,并进行文献复习,观察C-ALCL的组织学特征及免疫表型的特点。结果:该例为复发病例,两次均表现为皮肤结节;镜下肿瘤细胞异型性明显,体积较大;大细胞均表达CD30,部分大细胞表达EMA,不表达ALK-1;用CHOP方案治疗,患者预后较好。结论:C-ALCL是一种少见的原发于皮肤的淋巴瘤,肿瘤细胞表达CD30,EMA可阳性,一般不表达ALK-1,预后较好。Objective: To explore the clinicopathologic character of primary cutaneous anaplastic large cell lymphoma (C- ALCL). Methods: Clinical manifestations,histopathology and immunochemistry were studied in this recrudescent case and correlate literatures were reviewed. Results: The recrudeseent patient presented with cutaneous mass twice. Histopathologieally, the lesions were composed of anaplastic pleomorphic cell, all of these cells were positive for CD30, partial cells expressed EMA and negative for ALK-1. The patient got good prognosis after treated with CHOP regimen. Conclusion: Among the cutaneous lymphoma, C-ALCL is an uncommon subtype with good prognosis. Tumor cells are positive for CD30, some may be positive for EMA , but negative for ALK- 1. All available clinical and histological factors and immunophenotype should be considered in order to etablish the correct diagnosis.
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