注意缺损多动障碍关联于DXS7位点  

Association of Attention-Deficit Hyperactivity Disorderand the DXS7 Locus

作　　者：江三多[1] 忻仁娥[1] 林嗣萃[1] 钱伊萍[1] 江开达[2] 任大明[3] 汤国梅[1] 汪栋祥[1] 严和骏[1] 

机构地区：[1]上海市精神卫生中心,上海200032 [2]上海医科大学精神医学教研室,上海200032 [3]复旦大学遗传研究所,上海200032

出　　处：《遗传》1999年第2期7-10,共4页Hereditas（Beijing)

摘　　要：采用单体型相对风险和传递／不平衡检验方法，在中国人群中对注意缺损多动障碍（ADHD）与DXS7位点进行了遗传关联分析。结果表明，以父母双亲为对照，DXS7位点157bp等位基因与ASHD具有显著关联（χ2=9．10，P＜0.05）并连锁(χ2=953，P＜0.05)．提示，ADHD关联和连锁于DXS7位点。The present study was designed to assess the genetic association between attention-deficithyperactivity disorder(ADHD) and DXD7 locus polymorphism in Chinese population, with haplotype-based haplotype relative risk(HHRR) and the transmission/ disequilibrium test(TDT) analysis. We foundsignificant association(x2=9.10, P< 0.05) and linkage (x2=9.53, P<0.05) between the 157bp DXS7 alleleand DSM-Ⅲ-R-diagnosed ADHD(N = 54) in trios composed of father, mother and affected offspring.Our results suggest that ADHD was associated and in linkage with DXS7 locus.

关 键 词：注意缺损多动障碍 DXS7位点 关联 连锁 

分 类 号：R746.02[医药卫生—神经病学与精神病学]