肠道共生细菌和肠上皮屏障间关系的研究进展  

Development of relationship between intestinal commensal bacteria and intestinal epithelial barrier

作　　者：施君(综述)[1] 何振娟(审校)[1] 

机构地区：[1]上海交通大学医学院附属新华医院儿内科,200092

出　　处：《国际儿科学杂志》2010年第6期597-600,共4页International Journal of Pediatrics

摘　　要：人类出生后，其胃肠道黏膜表面与肠道共生细菌和致病性病原体密切接触。肠道上皮屏障作为抵御细菌人侵的第一道防线，通过模式识别受体产生对致病性病原体杀伤性免疫应答，而对共生细菌产生保护性应答。肠上皮细胞在对共生细菌形成免疫耐受，维持肠道免疫稳态中发挥重要作用。共生细菌能协助肠道上皮抵御病原体侵袭，并调节肠道免疫发育和免疫功能。在共生细菌和宿主肠道之间形成免疫平衡，否则易引起肠道炎症疾病。该文从共生细菌对宿主肠道的作用、肠上皮屏障对共生细菌形成免疫耐受机制以及肠道上皮屏障对共生细菌识别平衡破坏引起的疾病等多方面对共生细菌和肠上皮屏障之间关系作一综述。After birth, human intestinal tract mucosa is exposed to a large community of commensal and pathogenic bacteria. As a first line of defense, the intestinal epithelial barrier （IEB） kills the pathogen by signaling to the innate immune system, through pattern recognition receptors, while it produces protective respond towards the commensal bacteria. Intestinal epithelial ceils play an important role in forming immune tolerance to the commensal bacteria and make intestinal homeostasis. Commensal bacteria can resist the pathogenic bacteria invasion. The signals of commensal are required for development of intestinal epithelial barrier and intestinal innate and adaptive immunity. It is essential for the host to have a balance between the commensal bacteria and intestinal tract, once the balance is broken, the intestinal inflammation disease will be caused. Thus, this review will discuss the relationship between intestinal commensal bacteria and intestinal epithelial barrier in several aspects, such as the role of the commensal bacteria, the mechanism of producing commensal tolerance by IEB and the disease caused by imbalance between the commensal and IEB.

关 键 词：共生细菌 肠上皮屏障 肠粘膜上皮细胞 免疫耐受 

分 类 号：R573.1[医药卫生—消化系统]