P-gp在大肠癌中的表达及临床意义  

EXPRESSION AND CLINICAL SIGNIFICANCE OF P-GP IN COLORECTAL CARCINOMA

作　　者：李旭强[1] 王慧[1] 郑纪宁[1] 

机构地区：[1]承德医学院,河北承德067000

出　　处：《承德医学院学报》2010年第4期356-357,共2页Journal of Chengde Medical University

摘　　要：目的:探讨大肠癌组织多药耐药基因(MDR-1)产物P-糖蛋白(P-gp)表达与大肠癌临床病理特征的关系。方法:采用免疫组织化学染色法检测80例大肠癌组织P-gp的表达情况,对其临床病理学因素进行分析。结果:80例大肠癌患者中,P-gp阳性表达率为43.75%(35/80)。P-gp表达与大肠癌的分化程度、浸润深度、临床分期及淋巴结转移无关(P>0.05;)与年龄有关,≥60岁者P-gp的阳性表达率明显低于60岁以下者(P<0.01)。结论:大肠癌组织P-gp的表达率较高,并且与年龄相关,临床检测P-gp对选择个体化化疗方案具有重要意义。Objective：To investigate the relationships between multidrug resistance gene product P-gp expression and the clinical pathological characteristics in human colorectal carcinoma.Methods：P-gp expression in 80 cases of colorectal carcinoma tissue were determined by SP immunohistochemical staining.Results：The positive rate of P-gp expression in colorectal carcinoma was 43.75% （35/80）. The P-gp expression had no relations with differentiation degrce, clinical stage, infiltration depth and lymph node metastasis （P〉 0.05）; But had relations with age, the positive rate of P-gp expression in colorectal carcinoma of patients≥ 60-year old was obviously lower than patients under 60 （P〈 0.01）.Conclusions：The P-gp expression in colorectal carcinoma is fairly high and has relations with age. It is very important to detect P-gp expression when determine individualization treatment.

关 键 词：大肠癌 P-GP 免疫组织化学 多药耐药基因 

分 类 号：R735.3[医药卫生—肿瘤]