卵巢两性母细胞瘤临床病理分析  

Gynandroblastoma:A Clinicopathologic Analysis

作　　者：何艳梅[1] 江炜[1] 李雷[1] 徐炼[1] 杨开选[1] 

机构地区：[1]四川大学华西第二医院病理科,四川成都610041

出　　处：《华西医学》2010年第10期1862-1864,共3页West China Medical Journal

摘　　要：目的探讨卵巢两性母细胞瘤的临床及病理组织学特征。方法观察总结2004年3月-2008年3月6例卵巢两性母细胞瘤的临床及病理学特征,以及免疫组化染色结果。结果患者以月经紊乱、闭经、绝经后阴道出血为主要临床表现。肿瘤含两种成分,即颗粒细胞和Sertoli-Leydig细胞,两者均呈成熟性的组织学形态,1例伴有异源性分化成分。6例肿瘤呈α-inhibin和vimentin强阳性,3例呈CD99阳性,5例呈calretinin阳性,2例的Sertoli细胞呈CK阳性。4例患者有随访资料,随访期14～60个月,均无瘤存活。结论两性母细胞瘤以内分泌异常相关症状为主要临床表现,大部分患者诊断时处于临床1期,预后较好。对诊断为两性母细胞瘤的患者应进行长期的临床随访。Objective To observe the clinical pathologic and immunophenotypic features of gynandroblastoma.Methods The pathologic samples of six patients with gynandroblastoma from March 2004to March 2008were observed and analyzed.Immuohistochemistry staining was performed by SP method using antibodies ofα-inhibin,CD99,Vimentin,Calretinin,CK,EMA.Results The main clinical features included menstrual disorders,amenorrhea,and postmenopausal bleeding.The tumor was composed of ranulose cells and Sertoli cells,both of which were well differentiated.Strongly positive expression ofα-inhibin and vimentin was found in all the patients,while CD99（＋） was in three,calretinin（＋）was in five,and CK（＋）of Sertoli cells was in two.Four patients were followed up for 14-60months and all were tumor free.Conclusion The main clinical features of gynandroblastoma are estrogenic or androgenic manifestations.Nearly all the patients are diagnosed in stage 1and have a good prognosis.Patients with gynandroblastoma should be followed up for a long period.

关 键 词：卵巢 两性母细胞瘤 临床病理 免疫组织化学 

分 类 号：R737.31[医药卫生—肿瘤] R446.8[医药卫生—临床医学]